Aneuploidy Clinical Trial
Official title:
PErsonalized Genomics for Prenatal Abnormalities Screening USing Maternal Blood : Towards First Tier Screening and Beyond
This project aims to provide high- quality evidence to inform decisions by health care organisations about using first-tier non-invasive prenatal screening (NIPS) to replace traditional screening tests for trisomy 21, and potentially to screen for other fetal chromosome anomalies. We will compare the current screening approach of second-tier NIPS with the use of first-tier NIPS in a large cohort of pregnant women.
There is some data on the performance of NIPS as a first tier screening test but our systematic review has shown that no trial comparing the effectiveness (utility) of 2nd-tier NIPS with that of first-tier NIPS has been published . Further it is important for health care decision makers to have evidence produced in Canada since the geographical context of healthcare can affect uptake as well as patient decision and thus their healthcare trajectories. There is a need for a trial that is between an explanatory trial and a pragmatic trial to provide the types of answer that we aim to document in the present state of knowledge on NIPS-based screening strategies in Canada. Our Objective is to perform a pan-Canadian large-scale comparative utility (clinical outcomes) study of first-tier NIPS (expanded or not) as compared to the new standard of care (NIPS as a 2nd tier test performed much later during pregnancy and only in high risk pregnancies). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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| Recruiting |
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| Completed |
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| Completed |
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| Completed |
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N/A | |
| Recruiting |
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N/A | |
| Completed |
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Aneuploidy Rates of in Vitro Matured Oocytes
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| Recruiting |
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RCT Study to Validate niPGT-A Clinical Benefit.
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N/A | |
| Recruiting |
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Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
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| Active, not recruiting |
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A Time-lapse Monitoring Prospective Study
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| Active, not recruiting |
NCT05492981 -
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women?
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N/A | |
| Completed |
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Effect of Video Education on Patients' Knowledge and Attitudes of Privacy in Prenatal Genetics
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N/A | |
| Completed |
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Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies
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N/A | |
| Completed |
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| Terminated |
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Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial
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