Effects of Prenatal Alcohol Exposure on Emotional and Cognitive Abilities in Adults — ALTEMO  

Prenatal Alcohol Exposure Clinical Trial

Official title: Behavioral Exploration of Cognitive and Emotional Alterations in Adult Individuals Exposed to Alcohol During the Prenatal Period

Status Active, not recruiting

Clinical Trial Summary

Hypothesis:

Individuals presenting with prenatal alcohol exposure (PEA) show emotional abilities deficits, and imbalance between the two systems involved in decision-making according to dual-process models, namely an under-activated reflective system (involved in deliberate behaviors) and an over-activated affective-automatic one (involved in impulsive behaviors).

Primary objective:

To explore performance (as a percentage of correct answers) in an emotional facial expression decoding task in PEA participants compared to controls without alcohol disorder.

Clinical Trial Description

Each participant will undergo 2 visits :

First visit :

• Checking inclusion and non-inclusion criteria

• Note of information and consent form

• Record of concomitant treatments and anamnestic elements

• Alcohol, Tobacco, and Toxic Consumption

• Urinary Toxicity Test for Control Groups

• Laterality test (Hecaen, 1984)

• Brief visual and auditory acuity test

• Standardized psychiatric interview (Mini International Neuropsychiatric Interview - MINI)

Second visit = Experimental testing

• State-Trait Anxiety Inventory, Beck Depression Inventory, Inventory of Interpersonal Problems, Toronto Alexithymia Scale (TAS-20).

• Participant installation and testing: 6 behavioral tasks on a computer (also used to collect responses, except for task 2, see details below) :

Task 1 (MAIN): Test for recognition of facial emotions Task 2: 'Reading the Mind in the Eyes Test' (Decoding of complex emotional states) Task 3: Emotional evaluation of natural scenes Task 4: Target detection (measure of attentional bias towards alcohol-related stimuli) Task 5: Go / No-Go evaluating the interactions between inhibition processes and auto-affective system Task 6: "N-back" evaluating the interactions between working memory and automatic-affective system ;

Related Conditions & MeSH terms

• Prenatal Alcohol Exposure

• NCT number: NCT03793920
• Study type: Interventional
• Source: University Hospital, Lille
• Status: Active, not recruiting
• Phase: N/A
• Start date: November 8, 2018
• Completion date: November 11, 2022