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Premedication clinical trials

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NCT ID: NCT05946928 Completed - Clinical trials for Autism Spectrum Disorder

EMERGENCE AGITATION After Premedication IN PAEDIATRIC MAGNETIC RESONANCE IMAGING: A RETROSPECTIVE COHORT STUDY

premidazolam
Start date: March 1, 2022
Phase:
Study type: Observational

The aim of this study was to assess the anxiolytic and sedative effect of OZALIN® / OZASED® (ADV6209) 0,25mg/Kg in children undergoing magnetic resonance imaging (MRI) under inhalational anesthesia. Our hypothesis is that compared to children who do not receive any premedication, palatability of OZALIN® / OZASED® by allowing an easier acceptance of the drug, improves the quality of anesthesia induction and postoperative behavioral outcome improving sedation and reducing the need for inhalation anesthetic which has been recognized as the main cause of post-procedural behavioral changes, including emergence agitation.

NCT ID: NCT05604599 Completed - Analgesia Clinical Trials

Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS

Start date: November 10, 2022
Phase: Phase 4
Study type: Interventional

Intranasal dexmedetomidine provided good pharmacokinetic profile. However, intravenous dexmedetomidine have been used in functional endoscopic sinus surgery for several outcomes, there is lack in studies that had compared the efficacy of intravenous and Intranasal Dexmedetomidine for improving quality of the operative field in functional endoscopic sinus surgery. Therefore, we established this randomized study to compare intranasal dexmedetomidine with intravenous dexmedetomidine improving quality of the operative field in functional endoscopic sinus surgery.

NCT ID: NCT03603873 Completed - Anxiety Clinical Trials

Preoperative Anxiety Level, Premedications and General Anaesthetic Proceedings

Start date: March 3, 2017
Phase:
Study type: Observational

Although it seems obvious that the high level of preoperative anxiety may affect intraoperative anaesthetic requirements and recovery adversely, there are several contradictory studies about this subject. Furthermore, the effects of anxiolytic premedication are actually disputed: sedative premedication is widely administered but little clinical evidence supports its use. We want to evaluate the effects of pre-procedure anxiety for propofol needs in patients receiving general anaesthetic procedure. We also want to know if premedication is useful according to the preoperative anxiety level, in order to determine if a sub-group of patients benefit from it.

NCT ID: NCT03357718 Completed - Premedication Clinical Trials

Oral Dexmedetomidine vs Midazoam For Premedication

Start date: November 1, 2016
Phase: Phase 4
Study type: Interventional

The aim of this study was to compare the effect of 2 µg/kg of oral dexmedetomidine (DEX) and 0.5 mg/kg dormicum as premedication among children undergoing dental procedures.

NCT ID: NCT03325335 Completed - Premedication Clinical Trials

Assessing the Effectiveness of Midazolam Premedication

Start date: July 19, 2016
Phase: N/A
Study type: Interventional

Pre-anesthetic dosing of midazolam is commonly used in many hospitals for the induction of anesthesia, but the effect is still controversial. The purpose of this study was to evaluate the effectiveness of midazolam premedication in four aspects: anxiety reduction, pain relief, sedation and hemodynamic stability.

NCT ID: NCT03174678 Completed - Premedication Clinical Trials

Dexmedetomidine Premedication in Children

Start date: March 1, 2017
Phase: Phase 4
Study type: Interventional

The aim of this retrospective study was to detect the effectiveness of 1µg/kg oral dexmedetomidine premedication on preoperative cooperation and emergence delirium of the the young children underwent complete dental treatment.

NCT ID: NCT02700893 Completed - Clinical trials for Endotracheal Intubation

Cerebral NIRS Profiles During Premedication for Neonatal Intubation

Start date: March 2016
Phase: Phase 2/Phase 3
Study type: Interventional

Observational ancillary study of the PRETTINEO study (ClinicalTrials.gov Identifier: NCT01490580) which is a multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to endotracheal intubation of the neonate. Primary outcome: - Cerebral desaturation defined by a rScO2 delta >20% from the baseline value (before premedication). - Variation of more than 10% of cerebral FTOE (Fractional Tissue Oxygen Extraction) during premedication, calculated from rScO2 and pulse oximetry with the formula FTOE=SaO2 - rScO2/SaO2 . Hypothesis: "atropine + propofol" compared to "atropine+atracurium+sufentanil" does not increase the frequency of cerebral hypoxemia.

NCT ID: NCT02265822 Completed - Anaesthesia Clinical Trials

Melatonin Premedication in Children Undergoing Surgery

Start date: September 2012
Phase: Phase 4
Study type: Interventional

Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of melatonin premedication on the required infusion of propofol in comparison to midazolam, evaluating the efficacy of oral melatonin on sedation in children undergoing surgery. Preoperative anxiety and postoperative analgesia are also assessed in both groups.

NCT ID: NCT02072083 Completed - Premedication Clinical Trials

Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients

Start date: February 2014
Phase: Phase 4
Study type: Interventional

The aim of this study is using intranasal dexmedetomidine versus intranasal midazolam-ketamine combination for premedication and preventing the oculocardiac reflex of pediatric patients undergoing strabismus surgery.

NCT ID: NCT01490580 Completed - Clinical trials for Endotracheal Intubation

Premedication Trial for Tracheal Intubation of the NEOnate

PRETTINEO
Start date: May 2012
Phase: Phase 2/Phase 3
Study type: Interventional

Multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to endotracheal intubation of the neonate. Primary outcome: pulse oxymetry value < 80% for more than 60 seconds. Secondary outcomes: number of attempts, duration of the procedure, changes in physiologic parameters, short- and long-term neurodevelopmental outcome. Hypothesis: "atropine + propofol" compared to "atropine+atracurium+sufentanil" will significantly reduce the frequency of severe hypoxemia.