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Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants — NOSE  

Prematurity Clinical Trial

Official title:
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants - A Randomized Cross-over Study

Clinical Trial Summary

This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity. Infants on continuous positive airway pressure (CPAP) support will be included and the aroma will be applied to the inner surface of the CPAP mask using designated scent pens. The trial uses a cross-over design. Infants are randomised to begin the study with either aroma or placebo which will be applied into the breathing mask every 3 to 4 hours during 12 hours for each of the two intervention periods. Identically looking pens with either aroma or placebo are used and patients, parents, medical staff and the study team are blinded to this allocation. Infants are monitored with an oximetry sensor to measure peripheral oxygen saturation (SpO2) and pulse rate.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05878925
Study type Interventional
Source University of Zurich
Contact Janine Thomann, MD
Phone 0041432538774
Email janine.thomann@usz.ch
Status Recruiting
Phase N/A
Start date June 14, 2023
Completion date May 1, 2025
View Details
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