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Premature Ovarian Insufficiency clinical trials

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NCT ID: NCT05279560 Recruiting - Infertility, Female Clinical Trials

Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation

OPIF
Start date: March 17, 2022
Phase: N/A
Study type: Interventional

The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs. saline solution (NaCl) injection (Placebo) transvaginally or laparoscopically for follicular activation in patients with child wish and with low ovarian reserve/expected poor ovarian response planning to undergo IVF or ICSI using own eggs. Pain score as numerical rating score and validated quality of life questionnaire will be requested after the procedure. Longterm follow-up of all participants will be performed 1, 2 and 5 years after end of study.

NCT ID: NCT04167033 Recruiting - Clinical trials for Premature Ovarian Insufficiency

Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)

QT-IOP
Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP). The investigators have recently shown that estradiol determines an increase in QTc elongation and progesterone shortens it. In addition, high gonadotropin levels (FSH or LH) are associated with QTc prolongation. Hypergonadotropic hypogonadisms (low progesterone and high gonadotropins) are therefore hormonal situations that promote QTc prolongation. Premature ovarian insufficiency (POI) is one of them. Its management is based on the prescription of hormone replacement therapy (HRT). Epidemiological studies have shown that these patients would be at increased risk of cardiovascular mortality. Our team is interested in the effect of this pathological hormonal situation and its HRT on ventricular repolarization in order to define whether this is a population at risk for long QTc.