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Premature Labor clinical trials

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NCT ID: NCT05602883 Completed - Sleep Quality Clinical Trials

Music Therapy in the Threat of Premature Birth

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The scope of the study covers the effects of music therapy on risk perception levels and sleep quality in pregnant women hospitalized due to the diagnosis of premature birth threat.

NCT ID: NCT05477381 Recruiting - Preterm Birth Clinical Trials

Cervical Softening and the Prediction of Preterm Birth

STIPP
Start date: August 18, 2022
Phase:
Study type: Observational

Currently, transvaginal cervical length measurement is used to screen in asymptomatic pregnant women with a history of PTB. In symptomatic women, presenting with threatened PTB cervical length in combination with the fibronectin test is used to identify women at high risk to deliver preterm. However, the predictive capacity of transvaginal cervical length measurement is limited. In pregnant women with a history of PTB, it only identifies a proportion of women who will have recurrent PTB. For symptomatic women, 30-60% of these women admitted to the hospital, do not deliver within seven days, leading to overtreatment of these women. Cervical softening is precursor of cervical shortening, effacement and dilatation and therefore cervical softening is a promising new marker that is based on tissue elasticity. However, the predictive value of cervical softening and the relation with spontaneous PTB still has to be determined. With the newly developed Pregnolia® System cervical softness could be measured on a standardized and safe manner. This study could help to improve care for women with a history of spontaneous PTB.

NCT ID: NCT03223324 Completed - Premature Labor Clinical Trials

Performance of the Monica Novii Wireless Patch System in Threatened and Actual Pre-Term Labour

Start date: July 2, 2016
Phase:
Study type: Observational

To study the equivalence of the Monica Novii™ Patch System in patients admitted for threatened pre-term labor and for pre-term labor & delivery from 32 +0 weeks gestation by determining the equivalence of the Novii™ Patch System in monitoring Fetal Heart Rate (FHR), Maternal Heart Rate (MHR) and Uterine Contractions (UC) to Doppler FHR, tocodynamometer (TOCO) UC and photo plethysmograph MHR FDA approved predicates

NCT ID: NCT03057275 Completed - Premature Labor Clinical Trials

Performance of the Monica Novii Wireless Patch System in Pre-term Labor

Start date: April 20, 2017
Phase:
Study type: Observational

To study the equivalence of the Monica Novii™ Patch System in patients admitted for threatened pre-term labor and for pre-term labor & delivery from 32 +0 weeks gestation by determining the equivalence of the Novii™ Patch System in monitoring Fetal Heart Rate (FHR), Maternal Heart Rate (MHR) and Uterine Contractions (UC) to Doppler FHR, tocodynamometer (TOCO) UC and photo plethysmograph MHR FDA approved predicates.

NCT ID: NCT02793700 Completed - Premature Labor Clinical Trials

Pharmacokinetics (PK) and Modeling of Betamethasone Therapy in Threatened Preterm Birth

Start date: July 2016
Phase:
Study type: Observational

Respiratory distress syndrome (RDS) is a life-threatening condition for premature neonates. Antenatal glucocorticoids have been used clinically in women with threatened preterm birth to accelerate lung maturation for more than 40 years. The current treatment strategy for women with threatened preterm delivery is for a standard, "one size fits all" dosing with either betamethasone (BMZ) or dexamethasone. It is well known that pregnancy introduces additional variability in response to medication therapy with different physiological changes and alterations in the activity of drug metabolizing enzymes. The objective of this project is to evaluate the pharmacokinetic (PK), pharmacodynamic, and pharmacogenetic parameters of betamethasone (BMZ) and determine the differences in response and benefit in pregnancy. An individualized dosing approach to medications in pregnancy, such as BMZ, is crucial to optimize efficacy of this important medication.

NCT ID: NCT02569216 Withdrawn - Premature Birth Clinical Trials

Electrical Inhibition (EI): A Preliminary Study To Inhibit Preterm Labor And Preterm Birth

EI
Start date: February 9, 2016
Phase: Phase 1
Study type: Interventional

An electrical-inhibition (EI) uterine pacemaker device similar to an electrical heart pacemaker delivers a weak electrical current to the human uterus during active preterm labor to rapidly and safely inhibit the unwanted premature uterine contractions and possibly a preterm birth.

NCT ID: NCT02451228 Completed - Pregnancy Clinical Trials

Indomethacin PK and PD Therapy in Pregnancy

Start date: May 2015
Phase:
Study type: Observational

This study will follow pregnant women who are taking indomethacin as Standard of Care (SOC) for the indications of preterm labor (PTL), short cervix, or other indications, to evaluate the pharmacokinetics (PK), what the body does to the drug, and pharmacodynamics (PD), effectiveness of the drug in treating the specific intended disease process of this medication. This will help us develop more information for medication dosing specific to pregnant women experiencing preterm labor. Indomethacin is often prescribed to pregnant women presenting with preterm labor or shortened cervix, which places them at risk for preterm labor and delivery. Indomethacin has been used since the 1970s to prolong pregnancy by decreasing uterine contractions. However, despite the widespread use of indomethacin in pregnancy, there is limited information available to help physicians determine how much indomethacin to prescribe and how often to prescribe it.

NCT ID: NCT01022619 Not yet recruiting - Clinical trials for Gestational Diabetes

The Association Between High Risk Pregnancy and Sleep-disordered Breathing

Start date: January 2010
Phase: N/A
Study type: Observational

The aim of the present study is to establish, using polysomnographic criteria and prospective nature, whether sleep apnea in pregnancy is more prevalent in women with high risk pregnancies including preeclampsia, gestational diabetes, and pre-mature contractions, and to determine the effect of sleep disordered breathing in pregnancy on fetal outcome. The investigators' hypothesis is that sleep-disordered breathing is more prevalent in women with high risk pregnancy compared to those with uncomplicated pregnancy.

NCT ID: NCT00873314 Completed - Premature Labor Clinical Trials

Bed Rest for Threatened Preterm Labor. Pilot Study

Start date: July 2006
Phase: N/A
Study type: Interventional

The aim of the pilot trial is to assess at what extend women with arrested threatened preterm labor change their activity patterns at home in response to bed rest prescription. An area of concern for the design of a trial is the strength of health provider's recommendation to change women's behaviors, and their compliance with bed rest recommendations. The study was a randomized parallel design. The intervention group consisted of total bed rest for four days (with allowance to go to the toilet). The control group consisted in the restriction of activities during four days.

NCT ID: NCT00457925 Completed - Premature Labor Clinical Trials

Absorption, Distribution, Metabolism And Excretion Study For GSK221149A

Start date: October 2006
Phase: Phase 1
Study type: Interventional

This is a phase one study investigating the absorption, distribution, metabolism and excretion of GSK221149A in six healthy women of non-child bearing potential.