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Premature Ejaculation clinical trials

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NCT ID: NCT00983736 Terminated - Clinical trials for Premature Ejaculation

Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation

Start date: October 2009
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to test an experimental drug therapy called Tramadol Hydrochloride (HCl) Orally Disintegrating Tablets (ODT) ("Tramadol HCl ODT" or the "study drug"). The patient and the patient's partner are being asked to be in this clinical trial because they have a condition called Premature Ejaculation.

NCT ID: NCT00983151 Terminated - Clinical trials for Premature Ejaculation

Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation

Start date: August 2009
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to test an experimental drug therapy called Tramadol Hydrochloride (HCl) Orally Disintegrating Tablets (ODT) ("Tramadol HCl ODT" or the "study drug"). The subject and his partner are being asked to be in this clinical trial because they have a condition called premature ejaculation.

NCT ID: NCT00861484 Completed - Clinical trials for Premature Ejaculation

Proof of Mechanism in ELT

PoM
Start date: November 26, 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine if the administration of GSK958108 can delay ejaculation in patients with primary premature ejaculation as measured by the ejaculatory latency time (ELT) using the masturbation model and sexual visual stimulation, and to evaluate the safety and tolerability of GSK958108 in healthy men with PE

NCT ID: NCT00664365 Completed - Clinical trials for Premature Ejaculation

FTIH Study With GSK958108

Start date: April 12, 2008
Phase: Phase 1
Study type: Interventional

This study is the first administration of GSK958108 to man. The study will evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK958108 and evaluate the effect of food on GSK958108 pharmacokinetics

NCT ID: NCT00656552 Not yet recruiting - Clinical trials for Premature Ejaculation

Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation

Start date: May 2008
Phase: Phase 0
Study type: Interventional

Escitalopram has been claimed to have the highest selectivity for the human serotonin transporter relative to the noradrenaline or dopamine transporters. This might be associated with greater clinical efficacy. Most adverse events reported by escitalopram-treated patients are mild and transient. In this study, we compare escitalopram with placebo in the treatment of PE.

NCT ID: NCT00556478 Completed - Clinical trials for Premature Ejaculation

Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation

PSD502-PE-002
Start date: October 2007
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness, safety and tolerability of the investigational drug, PSD502 in subjects with premature ejaculation (PE) The study drug, PSD02, is a metered dose (measured dose), topical (applied to the skin surface) anesthetic (numbing) spray containing a mixture of lidocaine and prilocaine. The study drug will be applied in a spray to the penis prior to intercourse in order to decrease sensitivity in an attempt to delay ejaculation.

NCT ID: NCT00549211 Completed - Clinical trials for Premature Ejaculation

A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296.

Start date: October 2007
Phase: Phase 1
Study type: Interventional

A study conducted on healthy volunteers to determine the safety, tolerability and affect on the human body by experimental drug GSK557296.

NCT ID: NCT00537459 Completed - Clinical trials for Premature Ejaculation

A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation

Start date: December 2006
Phase: Phase 2
Study type: Interventional

16448 is being investigated for the treatment of primary premature ejaculation (PE) using a novel mode of action. There are no approved therapies for premature ejaculation, and novel therapies are needed for this syndrome. 16448 has been shown to increase ejaculatory latency in the PCA rat model of premature ejaculation. A novel instrument, the Sexual Assessment Monitor (SAM), will be used to measure ejaculatory latency time in this study. This device, which measures ELT under standard conditions, has been shown to provide a more reliable measure of ejaculatory latency compared to the use of a stopwatch during sexual intercourse

NCT ID: NCT00449709 Terminated - Clinical trials for Premature Ejaculation

A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects

Start date: March 2007
Phase: Phase 1
Study type: Interventional

PreTerm Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor. GSK221149 is an experimental drug that will be used to block the effects of oxytocin, and therefore pause or prevent contractions. In this study, the pharmacokinetics of various modified release formulations of GSK221149 will be investigated in healthy non-pregnant adult subjects.

NCT ID: NCT00370981 Completed - Clinical trials for Premature Ejaculation

Exploratory Study of Pagoclone in Men With Premature Ejaculation.

Start date: July 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate pagoclone in the treatment of premature ejaculation.