Premature Birth Clinical Trial
Official title:
Spectroscopic-chemometric Determination of Lecithin-sphingomyelin Ratio in Gastric Aspirates and Secretion From Hypopharynx at Birth, in Relation to Development of RDS
The overall objective is to identify quickly after birth the preterm infants who will
develop respiratory distress syndrome (RDS) for the purpose of treating them as early as
possible with surfactant, to reduce, and if possible, to avoid sequelae, including long-term
oxygen treatment.
We have therefore developed a quick test, which we believe will be ideal for this type of
diagnostics, and will now test the method in a preclinical trial.
In at least 135 preterm infants with gestational age 24-32 weeks we will collect gastric
aspirate and hypopharyngeal secretion. The infants are stratified into three groups:
gestational age 24-25 weeks, 26-29 weeks and 30-31 weeks.
The aspirates will be frozen at -20 centigrade and lecithin-sphingomyelin ratio (L/S) will
be analysed retrospectively using Fourier Transform Infrared Spectroscopy.
The infants will be monitored for the first five days with regard to possible development of
RDS.
Clinical and biochemical data will be compared retrospectively.
There a no intervention procedures.
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Observational Model: Case Control, Time Perspective: Retrospective
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