Premature Birth Clinical Trial
Official title:
Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks: A Randomized Controlled Trial
The overall objective of the present study is to examine the effects of delayed umbilical
cord clamping in preterm infants on neonatal outcomes using a prospective randomized
controlled trial comparing immediate cord clamping (standard at present) with delayed cord
clamping.
Our specific aim is to determine if a 30 to 45 second delay in umbilical cord clamping
improves neonatal outcome as assessed by a composite of intraventricular hemorrhage and late
onset sepsis in preterm infants born between 24 and 32 weeks gestation. Secondary outcomes
to be examined include improvements in the following: 1) lung function as assessed by oxygen
dependency at 36 weeks corrected gestational age (CGA), 2) cardiovascular function as
assessed by the need for volume expansion, inotropes, or clinically suspected PDA requiring
intervention prior to discharge home, and 3) anemia as assessed by initial hemoglobin, need
for transfusion during stay in the NICU, and number of transfusions.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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