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NCT00460044 Clinical Trial

ADMA and Mechanical Ventilation in Preterm Infants

Premature Birth Clinical Trial

Official title:
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00460044
Other study ID # HK0607
Secondary ID
Status Completed
Phase N/A
First received April 11, 2007
Last updated April 12, 2007
Start date January 2002
Est. completion date July 2003

Study information
Verified date April 2007
Source VU University Medical Center
Contact n/a
Is FDA regulated No
Health authority Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Study type Observational

Clinical Trial Summary

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

Description:

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Recruitment information / eligibility
Status Completed
Enrollment 35
Est. completion date July 2003
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A to 32 Weeks
Eligibility Inclusion Criteria:

- Gestational age < 32 weeks

- Birth weight < 1500 gram

- Written informed consent of parents

Exclusion Criteria:

- Congenital abnormalities

- Chromosomal abnormalities

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
VU University Medical Center
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