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Premature Birth clinical trials

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NCT ID: NCT01050192 Withdrawn - Prematurity Clinical Trials

Nutritional Content of Breast Milk From Mothers of Premies

Start date: December 2009
Phase: N/A
Study type: Observational

The purpose of this study is to determine the correlation, if any, between the nutritional content of breast milk pumped by the mothers of very low birth weight (VLBW) infants in the neonatal intensive care unit (NICU) and the nutritional value they are actually receiving in a 24 hour period, since as a practical matter, these may not be the same.

NCT ID: NCT00691418 Withdrawn - Premature Birth Clinical Trials

Docosahexaenoic Acid (DHA) Administration and Length of Gestation: a Feasibility Study

Start date: July 2008
Phase: N/A
Study type: Interventional

This is a feasibility study to determine if it will be possible to conduct a larger study of the effect of docosahexaenoic acid (DHA), an omega fatty acid, on increased length of gestation among women who have had a previous preterm delivery.

NCT ID: NCT00582374 Withdrawn - Preterm Birth Clinical Trials

Periodontal Disease and Preterm Birth

Start date: March 2005
Phase: N/A
Study type: Observational

To determine the relationship between periodontal disease and upper genital tract inflammation in pregnancy. To determine whether certain fluid levels in the oral cavity and the vagina are associated with preterm birth or low-birth weight.

NCT ID: NCT00580099 Withdrawn - Growth Clinical Trials

Assisted Exercise in Prematurity; Effects and Mechanisms

Start date: February 2006
Phase: N/A
Study type: Interventional

Briefly our study is looking at the effects of 4 weeks of assisted exercise on the body composition and neurological/behavioral development of healthy growing premature infants enrolled between the ages of 30-33 weeks. It is a blinded study where the active group gets the exercise intervention and the control group is cuddled for the same amount of time -approximately 20 minutes. We get baseline data using muscle ultrasound, bone speed of sound and DEXA. We also get baseline blood samples to look at inflammatory mediators and growth hormone. Video of each subject is recorded an hour at two time points during the study to assess the babies for spontaneous activity. Nutritional intake information is collected daily and in the 4th week of the study assessments made for total energy expenditure using doubly labeled water. At this point in the study we repeat the ultrasounds and DEXA for comparison. Finally in the period just before discharge we do a complex neurological exam using the Brazelton NBAS assessment.

NCT ID: NCT00564161 Withdrawn - Clinical trials for Preterm Infants With White Matter Damage

VEGF as a Prognostic Factor for White Matter Damage in Preterm Infants

Start date: January 2008
Phase: N/A
Study type: Observational

We hypothesize that misexpression of vascular endothelial growth factor (VEGF) in the Cerebrospinal fluid of preterm infants can be used as a biomarker to predict the risk for developing white matter damage.

NCT ID: NCT00563121 Withdrawn - Clinical trials for Retinopathy of Prematurity

VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and V

Start date: March 2007
Phase: Phase 4
Study type: Interventional

To determine the degree of VEGF in Aqueous, vitreous and SRF in patients with ROP in stage V. Verifying that it is greater to that found in healthy newborn patients with different ocular pathology.

NCT ID: NCT00536445 Withdrawn - Infant, Premature Clinical Trials

Use of NAVA in Intubated Preterm

Start date: October 2007
Phase: Phase 1/Phase 2
Study type: Interventional

The present protocol will demonstrate the feasibility and efficacy of a newly developed mode of mechanical ventilation, Neurally Adjusted Ventilatory Assist, commonly known as NAVA. During NAVA, the timing and magnitude of pressure delivered are controlled by the infants' diaphragm electrical activity (EAdi), a validated measurement of neural respiratory drive. Recent clinical trials in adults and term infants have shown that NAVA is more synchronous than conventional pressure support ventilation, and that NAVA delivers lower mean airway pressures to achieve the same ventilation and respiratory muscle unloading. NAVA has recently been approved for use in neonates by Health Canada and the FDA in the United States, and is commercially available on the Servoi ventilator (Maquet Critical Care, Solna, Sweden). The present protocol is designed as a "case study" where the researchers responsible would like to evaluate the feasibility and efficacy of ventilating a premature baby on NAVA with the Servoi for 12 hours.

NCT ID: NCT00370019 Withdrawn - Clinical trials for Premature Ovarian Failure

Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure

Start date: August 25, 2006
Phase: Phase 2
Study type: Interventional

This study will determine whether giving estrogen replacement therapy through an estradiol patch can improve ovulation rates in women with spontaneous premature ovarian failure. The ovaries are glands in women that produce female hormones and normally release an egg once a month. In women with spontaneous premature ovarian failure, the ovaries stop working too soon. Women with this disorder have abnormally high levels of leuteinizing hormone (LH) in their blood, which impedes normal ovulation. In some women, estrogen replacement can suppress LH levels to the normal range. Women between 18 and 40 years of age with premature ovarian failure may be eligible for this 4-month study. Participants receive either standard hormone replacement therapy, consisting of an estradiol patch and progestin tablets, or placebo. The placebo group receives patches and tablets that look the same as those for the group with active treatment but they contain no hormone. All participants wear the patch every day and take the tablets the first 12 days of each month. In addition to taking the study drug, participants have blood drawn once a week for the 16 weeks of the study. At the end of the trial, women who were in the placebo group are offered the opportunity to receive the estrogen patch and progestin therapy for another 16 weeks and continue the blood tests to determine if they ovulate on this treatment.

NCT ID: NCT00329316 Withdrawn - Pregnancy Clinical Trials

Prevention of Recurrent Preterm Delivery by a Natural Progesterone Agent

Start date: n/a
Phase: N/A
Study type: Interventional

To examine the preterm delivery rate of a preterm delivery high risk group of pregnant women, using once daily natural progesterone agent.

NCT ID: NCT00217308 Withdrawn - Premature Birth Clinical Trials

Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery

Start date: February 2005
Phase: Phase 1
Study type: Interventional

Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.