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Premature Birth clinical trials

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NCT ID: NCT04118400 Enrolling by invitation - Clinical trials for Respiratory Distress Syndrome in Premature Infant

Ventilator Weaning Outcome Between NIV-NAVA and Nasal CPAP (or IMV ) Modes in Premature Neonates

Start date: October 31, 2019
Phase:
Study type: Observational [Patient Registry]

Premature neonates are prone to respiratory distress and need ventilator support because of the rapid breathing and large variations in respiratory patterns. The setting and adjustment of the ventilator for premature neonate is not easy, often resulting in poor patient-ventilator interaction, increased work of breathing, patient discomfort and delayed weaning . Recently, a new ventilation mode (NAVA; Neurally Adjusted Ventilatory Assist) mode, allows the respirator to provide a proportional ventilation mode based on the patients' diaphragm electrical activity, which was validated in many domestic and international clinical researches. The NAVA mode improves patient-ventilator interaction, reduces work of breathing and contributes to early weaning and extubation . When participating in this study, the neonate with receive a special oral tube placement, which is used to replace the original gastric tube to monitor the electrical activity of the diaphragm.

NCT ID: NCT04009473 Enrolling by invitation - Menopause Clinical Trials

Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation

SEGOVA
Start date: June 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

SEGOVA procedure includes - Stem cell therapy, G - Growth factor Platelet Plasma Rich therapy and in Vitro Activation of the ovaries.

NCT ID: NCT03755999 Enrolling by invitation - Preterm Infant Clinical Trials

A Cue-based Developmental Approach Toward the Preterm Infants During Feeding Transition Period

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The coordination of sucking, swallowing, and breathing during the transition from gavage to oral feeding is a challenge for preterm infants. Efficient management of the feeding transition without other comorbidities can not only improve their oral movements and gastrointestinal function development, facilitate their oral feeding learning behavior, but also facilitate them to direct breastfeeding, improve mother-infant attachment, and ultimately reduce the length of hospitalization. However, the current status of strategies in supporting preterm infants throughout their feeding transition are inconsistent, and lack of guidelines and monitor indicators based on existing evidence. This project proposed a three-year plan the explore the current situation, examine effective strategies for care bundles, and further develop a new clinical guideline that can be implemented in the future. The first year of this research will use chart review among two neonatal intensive care units of Medical Center from Taipei and Tainan. A semi-structured interview and questionnaire (DSCS-N) will be used to explore nurses' knowledge, attitude and skills of developmental care; and the experience of caring for preterm infants during feeding transition in the neonatal intensive care units. In addition, gestational age, body weight, gavage and oral feeding amount, and special events happened during feeding will be recorded and analyzed. The second year, an experimental with a stratified random assignment and repeated measure design will be used with feeding transition care bundles. 120 preterm infants will be recruited and assigned to experimental or control group. The subjects will be fed by the routine care approach or by the feeding transition approach in one neonatal intensive care unit. Intervention components include oral stimulation and cue-based feeding during the transition to oral feeding. Study measures will include physical indicators, POFRAS and EFS during feeding to evaluate the implementation and guide further development of the clinical guideline. The third year of guideline development will follow Bowker and the National Health Insurance Bureau which including 5 stage. The results of this guideline can offer better recommendations to support preterm infants' oral development, provide cue-based feeding, and help them succeed in the transition to oral nutrition.

NCT ID: NCT03212547 Enrolling by invitation - Preterm Infant Clinical Trials

The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal.

Start date: September 19, 2017
Phase: N/A
Study type: Interventional

The objective of this project is to determine the effect of the verbal intervention on the decrease in sustained social withdrawal in late and moderately late preterm infants. The intervention will be performed by pediatricians trained in the Alarm Distress Baby Scale (ADBB). This scale has been applied to term and preterm newborns in multiple international studies, but it has not yet been applied in Chile, nor with moderately late and late preterm infants. Infants are social beings who are born with innate reciprocal communication skills that can be observed during the two first months after delivery in babies with normal development. These skills include abilities to make and maintain eye contact, to vocalize and to use facial expressions, body and head movements to start interactions. Micro-analytical studies have demonstrated the frequent appearance of short episodes of social withdrawal affecting the infant during mother-baby interactions, whose function is to regulate the interaction flow. This behavior can be perceived when the infant needs to calm down or when is tired, and as a reaction to transitory interaction disturbances. In contrast with these short episodes of social withdrawal, the occurrence of sustained social withdrawal in infants is significantly less and is frequently associated with pathological conditions, such as autism spectrum disorder, child depression, and severe or chronic pain. Additionally, sustained social withdrawal is a symptom of anxiety and post-traumatic stress disorders. Different studies have revealed a prevalence of 11-22% in pre-term infant populations. In addition, the increase in sustained social withdrawal has been related to deviations of the interaction skills, attachment, as well as to relational and behavioral disorders. The increase and chronification of sustained social withdrawal, used as a defensive conduct, imply a risk to the adequate development of an infant's potential and raise the probability of alterations in the development of his psychopathology.

NCT ID: NCT03210415 Enrolling by invitation - Preterm Labor Clinical Trials

Study on Prevention, Treatment and Mechanism of Preterm Labor for Chinese Pregnant Women ≥35 Years Old

Start date: August 1, 2017
Phase:
Study type: Observational

In China, there's no effective prevention and treatment on preterm birth for pregnant women ≥35 years old, so this study is necessary.

NCT ID: NCT03061968 Enrolling by invitation - Premature Clinical Trials

Study of Applying Acupressure in Low-birth Weight Premature

Start date: May 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effects of acupressure application in very low birth weight premature.

NCT ID: NCT02241460 Enrolling by invitation - Clinical trials for Premature Ejaculation

Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation

Promescent
Start date: March 2014
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of treatment with Promescent Lidocaine Spray compared with placebo in patients with premature ejaculation.

NCT ID: NCT02050971 Enrolling by invitation - Clinical trials for Bronchopulmonary Dysplasia

Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates

Start date: October 2010
Phase: Phase 1
Study type: Interventional

The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of prematurity.

NCT ID: NCT01750775 Enrolling by invitation - Clinical trials for Premature Ventricular Contraction

Shensongyangxin Capsule in the Treatment of Sinus Bradycardia With Premature Ventricular Contractions

SS-SBVPT
Start date: August 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the effects of Chinese medicine Shansong Yangxin capsule for sinus bradycardia complicated with ventricular premature beats.

NCT ID: NCT01509248 Enrolling by invitation - Apea of Prematurity Clinical Trials

Population Pharmacokinetics and Metabolomics of Theophylline in Preterm Infants

Start date: May 2010
Phase: N/A
Study type: Observational

1. Population pharmacokinetics : The purpose of this study is - to investigate the population pharmacokinetics of theophylline in premature Korean infants and to assess the influence of demographic and clinical covariates. 2. Metabolomics : The purpose of this study are - to predict serum theophylline levels and to assess CYP1A2 activities in premature infants by analyzing urinary metabolites of theophylline - to examine which factors affect clearance of theophylline and CYP1A2 activity in premature infants