Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01748214
Other study ID # 13164
Secondary ID
Status Completed
Phase N/A
First received December 6, 2012
Last updated December 10, 2012
Start date November 2008
Est. completion date November 2010

Study information

Verified date December 2012
Source University of Virginia
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

Infants in neonatal intensive care units are increasing exposed to non-invasive ventilatory support modes (nasal continuous positive airway pressure - NCPAP and high flow nasal cannula: >1 L/min flow - HFNC). While there have been small descriptive studies of noise exposure in infants on NCPAP, there have been no comparative trials done comparing noise exposure in infants undergoing both NCPAP and HFNC.

Objective: Using a cross-over model determine noise exposure levels in infants exposed to similar levels of respiratory support provided by NCPAP and HFNC.


Description:

Infants born < 32 weeks, in an incubator, and > 7 days postnatal that were maintained on either on NCPAP or HFNC to maintain SaO2 in a range of 88 - 92 %. Study infants had decibel measurements obtained every 15 seconds for 30 minutes using a noise dosimeter (NoisePro DLX-1). The microphone for the dosimeter was suspended from the inside of the incubator such that it hung 1 foot above the infants nose and mouth. The exhalation port for NCPAP was placed outside of the incubator. Repeated measurement periods on the same mode of support were made within a 72 hour period. Each infant the acted as their own control and was switched within 7 days to the alternative respiratory support method that maintained similar SaO2 goals and repeat measurements were obtained. Comparisons of mean decibel levels during recording were compared using paired t-tests.


Recruitment information / eligibility

Status Completed
Enrollment 28
Est. completion date November 2010
Est. primary completion date November 2010
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- Premature infant born < 32 weeks and 0 days post-conceptional age;

- Seven or more days of age and not in acute respiratory distress;

- Need for nasal continuous positive airway pressure or high-flow nasal cannula for ventilation or supplemental oxygen delivery;

- In a neutral-thermal environment (i.e. isolette)

Exclusion Criteria:

- Oro-facial congenital anomalies;

- Congenital heart disease (except for patent ductus arteriosus and/or patent foramen ovale);

- Unstable respiratory status as deemed by the attending physician

- Patients under isolation for infectious disease

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective


Related Conditions & MeSH terms


Locations

Country Name City State
United States University of Virginia Health System Charlottesville Virginia

Sponsors (1)

Lead Sponsor Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Noise level Noise levels will be measured during a set time while infants are on Nasal CPAP and Nasal High flow cannula as standard of care 6 days No
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02452580 - The Norwegian Family Centered Care Study
Completed NCT02502916 - Enteral Feeding and Early Gut Colonization of Preterm Infants N/A
Terminated NCT02840825 - Biochip for HCMV Detection in Breast Milk
Recruiting NCT02306317 - The Adding Value of Parents to Nursing Care in the Control of FiO2 N/A
Completed NCT01354028 - Effects of Massage Therapy to Induce Sleep in Preterm Infants N/A
Completed NCT01881256 - The BabyGrow Longitudinal Study of Nutrition and Growth in Preterm Infants N/A
Completed NCT03001479 - Noninferiority Trial of Liquid Human Milk Fortifier (HMF) Hydrolyzed Protein Versus Liquid HMF With Supplemental Liquid Protein N/A
Completed NCT02788786 - Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal Phase 2
Completed NCT01678638 - Timing of Inguinal Hernia Repair in Premature Infants N/A
Recruiting NCT02623400 - The Effect of Perinatal Stress on the Development of Preterm Infants
Completed NCT02523222 - Prophylactic Dextrose Gel for Newborns at High-risk for Hypoglycemia N/A
Active, not recruiting NCT02508571 - Direct Swallowing Training and Oral Sensorimotor Stimulation in Preterm Infants N/A
Completed NCT02477423 - A Randomized Controlled Trial Investigating if Antibiotic Use in the First 48 Hours of Life Adversely Impacts the Preterm Infant Microbiome N/A
Completed NCT02478684 - Delayed Cord Clamping in Preterm Neonates N/A
Terminated NCT02040909 - Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation Phase 1
Completed NCT00722943 - Neuroendocrine Mechanisms of Developmental Massage Therapy (DMT) in Preterm Infants: Clinical Study N/A
Active, not recruiting NCT02832011 - How Effect Olive Oil and Eoprotin on Immunological Parameters and Growth N/A
Completed NCT02643472 - GPS (Giving Parents Support): Parent Navigation After NICU Discharge N/A
Terminated NCT01759134 - Comparison of Post-Discharge Growth of Premature Infants Using Two Different Formulas Phase 4
Completed NCT01628510 - The Developmental Effects of NICU Positioning N/A