High-risk Breast Lesions: A Multicenter Retrospective Study

Status Completed

Clinical Trial Summary

In this multicenter study, the goal was to document the excisional biopsy or follow-up results of high risk lesions diagnosed on image guided CNB/VAB, and evaluate the clinical, imaging and histologic features for associated malignancy risk. The possibility of upgrade related to histologic subtype, tissue sampling and other variables was also evaluated.

Clinical Trial Description

This is a retrospective multicentric study that include 1345 patients from 30 centers. Patients who had a diagnosis of high risk lesions (HRL) on image guided core biopsy (tru-cut/vacuum biopsy) were reviewed in a 12 year period (between 2008 and 2020). The lesions included were ADH, LN (ALH/LCIS), papilloma (without or with atypia), RS, and FEA. The patients who managed with an excisional biopsy or having at least 1 year follow-up documentation following the diagnosis of borderline lesion were included in the study. Radiological findings, diameter of lesion (>15 vs <15 mm), needle biopsy type (14-16G vs 9-12G), sampling method and number of samplings (4 and >4 vs <4) were documented. IBM SPSS Version 25.0 statistical package program was used for analysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04926688
Study type	Observational
Source	Ege University
Contact
Status	Completed
Phase
Start date	June 10, 2020
Completion date	June 10, 2021

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