The Effect of Periodontal Treatment on Stress and Pregnancy Relationship

Pregnancy Gingivitis Clinical Trial

Official title:

Relationship of Sex Steroid and Stress Markers in Saliva and Gingival Crevicular Fluid With Pregnancy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04315532
• Other study ID #: 2018.06.05.1298
• Status: Completed
• Phase: N/A
• Start date: April 2016
• Est. completion date: November 2016

Study information

• Verified date: March 2020
• Source: Tokat Gaziosmanpasa University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There is a relationship between stress and pregnancy gingivitis. This relationship may be double-sided.

Description:

The aim of this clinical study was to determine the effect of non-surgical mechanical periodontal treatment on sex steroid and stress markers at pregnancy gingivitis. A total of 84 subjects; 22 pregnant women with gingivitis (group 1) and 25 pregnant women with periodontal healthy (pregnant group), group 2), 22 non-pregnant women with gingivitis (group 3) and 15 non-pregnant women with periodontal healthy (non-pregnant group), group 4) participated in this study. Clinically, plaque index, gingival index, and probing pocket depth were measured at baseline and after therapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 84
• Est. completion date: November 2016
• Est. primary completion date: October 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 24 Years to 50 Years

Eligibility

Inclusion Criteria:

• being between the ages of 24-50

• being pregnant for 23-30 weeks (for pregnant individuals)

• not smoking.

Exclusion Criteria:

• using antimicrobial or anti-inflammatory therapy within the previous 3 months,

• having systemic disease,

• having periodontitis,

• having deep caries lesions, and remnant roots and

• having lactation

Related Conditions & MeSH terms

• Gingivitis
• Pregnancy Gingivitis

Intervention

Other:
• Non-surgical periodontal treatment
Non-surgical periodontal treatment was performed for pregnant and non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken from all patients baseline and after 8 weeks.
• Saliva samples
Saliva samples were taken from patients for the evaluation of sex steroid and stress markers baseline and after 8 weeks.
• GCF samples
GCF samples were taken from patients for the evaluation of stress markers baseline and after 8 weeks.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Tokat Gaziosmanpasa University	Abant Izzet Baysal University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dehydroepiandrosterone (DHEA)	The changes in DHEA levels within 8 weeks. Higher values represent a worse outcome. The decrease in DHEA levels is expected after periodontal treatment.	Baseline and after 8 weeks
Primary	estrogen	The changes in estrogen levels within 8 weeks. Higher values represent a worse outcome. The decrease in estrogen levels is expected after periodontal treatment.	Baseline and after 8 weeks
Secondary	Gingival index	The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.	Baseline and after 8 weeks