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Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment

Prediabetes Clinical Trial

Official title:
Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment：an Open-label, Multicenter，Randomized, Prospective，Controlled Study

Clinical Trial Summary

The aim of this study is to assess the beneficial effects of Bifidobacterium and Berberine Hydrochloride on lowering glucose and delaying progress to diabetes in patients with prediabetes and to detect the potential mechanism.

Clinical Trial Description

Gut microbiota may play an important role in patients with prediabetes. Berberine, which is usually used as an antibiotic drug, has been reported a potential glucose-lowering effect in vitro and in vivo studies. Bifidobacterium, as a familiar probiotics, can modulate gut microbiota and improve glucose and lipid metabolism in animal experiments. Therefore, the aim of this study is to assess the beneficial effects of Bifidobacterium and Berberine Hydrochloride on lowering glucose and delaying progress to diabetes in patients with prediabetes and to detect the potential mechanism. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02082756
Study type Interventional
Source Xijing Hospital
Contact
Status Withdrawn
Phase Phase 2/Phase 3
Start date November 2015
Completion date April 2018
View Details
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