Precancerous Condition Clinical Trial
Official title:
Molecular Epidemiology of Barrett's Esophagus
Verified date | January 2017 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
RATIONALE: A study that evaluates DNA changes and other disease-related health information
in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding
may help doctors learn more about the risk factors for Barrett's esophagus.
PURPOSE: This clinical trial is looking at DNA changes and other disease-related health
information as risk factors for Barrett's esophagus in patients with Barrett's esophagus,
gastroesophageal reflux, or gastrointestinal bleeding.
Status | Completed |
Enrollment | 170 |
Est. completion date | March 2013 |
Est. primary completion date | March 2013 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Undergoing elective esophagogastroduodenoscopy for any of the following reasons: - Surveillance of Barrett's esophagus - Evaluation of severe or refractory gastroesophageal reflux disease or chest pain thought to be due to reflux - Gastrointestinal bleeding PATIENT CHARACTERISTICS: - Not pregnant PRIOR CONCURRENT THERAPY: - Not specified |
Country | Name | City | State |
---|---|---|---|
United States | Harvard School of Public Health | Boston | Massachusetts |
United States | Massachusetts General Hospital Cancer Center | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Polymorphisms in detoxifying enzyme systems such as glutathione S-transferases (e.g., mu, theta, pi) | 2000-2013 | ||
Primary | Polymorphisms in other xenobiotic metabolism pathways (e.g., CYP1A1, CYP2E1, CYP3A4/5, NQO1, mEH, NAT-2) | 2000-2013 | ||
Primary | Polymorphisms in inflammatory gene pathways (e.g., MPO, MnSOD, IGF, IGFBF3, Il1-beta) | 2000-2013 | ||
Primary | Polymorphisms in DNA repair genes or the p53 pathways (e.g., ERCC2, XRCC1, p53, p73, CCND1, p21) | 2000-2013 |
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