Aged Clinical Trial
Official title:
The Influence of Prebiotic Supplementation on Intestinal Barrier Function in Elderly: A Randomized Placebo Controlled Clinical Trial
The investigators aim was to assess whether 6 weeks of oral intake of the wheat-derived prebiotic fiber arabinoxylan or oat-derived beta-glucan could improve intestinal barrier function against drug-induced barrier disruption in a general population of elderly people, in a randomized double blinded placebo-controlled clinical trial.
The study consisted of a 9 week clinical trial to which the study participants orally
ingested two different prebiotic compounds/one placebo for a total of 6 weeks.
The primary outcome was intestinal permeability which was measured before/after indomethacin
intake before starting with the prebiotic supplementation and repeated 6 weeks afterwards.
Indomethacin is an NSAID known to artificially increase the intestinal permeability. The
prebiotic fibers arabinoxylan and oat-derived beta-glucan have not been investigated for
their effect on intestinal permeability in older adults.
Intestinal permeability was investigated using the multi-sugar permeability test.
Participants ingested a water solution containing 5 sugar probes that are taken up in
different parts of the gut. These sugars are later recovered in the urine at two different
time points, reflecting gastroduodenal, small intestinal and colonic permeability.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT06454071 -
Immunologic Changes and Recovery-related Factors in Elderly Colon Cancer Patients
|
Phase 2 | |
| Completed |
NCT03297567 -
Physical Therapy Guidelines For Hospitalized Elderly
|
N/A | |
| Completed |
NCT00404118 -
Senior Coordinated Referral Study
|
N/A | |
| Not yet recruiting |
NCT04419753 -
The Role of Attention Focus Walking Training in Older Adults.
|
N/A | |
| Completed |
NCT03138265 -
HIT Training in the Frail Elderly.
|
N/A | |
| Completed |
NCT02598882 -
Virtual Reality as a Tool for Rehabilitation on Elderly People
|
N/A | |
| Completed |
NCT02598115 -
Impact of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older
|
N/A | |
| Completed |
NCT05447533 -
Clostridioides Difficile and Frailty
|
N/A | |
| Completed |
NCT04127539 -
Evaluation of Strong & Steady - Fall Preventive Group Exercise Program
|
N/A | |
| Completed |
NCT05586828 -
A Single-center Retrospective Cohort Study to Explore the Prognostic Significance of CONUT in Elderly CAD Patients With HFpEFand Compare CONUT With Other Objective Nutritional Indices.
|
||
| Completed |
NCT04536324 -
The Absorption Rate of Subcutaneous Infused Fluid
|
||
| Not yet recruiting |
NCT04516174 -
Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
|
N/A | |
| Completed |
NCT02918058 -
Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults
|
N/A | |
| Suspended |
NCT05107947 -
Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm
|
N/A | |
| Completed |
NCT03336177 -
Understanding Low Gynecological Cancer Delay and Help-seeking Behavior in Older Patients.
|
||
| Completed |
NCT06095661 -
Virtual Reality as a Postoperative Pain Management Adjunct in Older Adults: An Acceptability and Feasibility Study
|
N/A | |
| Completed |
NCT04715971 -
Urinary Retention on an Acute Geriatric Hospitalisation Unit.
|
||
| Recruiting |
NCT04327115 -
Study of an Physical Exercise Program on Older People of 75 Years Old and More, Hospitalized in Geriatric Short Stay
|
N/A | |
| Recruiting |
NCT04128410 -
A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients
|
||
| Completed |
NCT02181062 -
Culturally Tailoring a Stroke Intervention in Community Senior Centers
|
N/A |