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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06414655
Other study ID # ChiTwiMC
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date March 1, 2024
Est. completion date November 30, 2026

Study information

Verified date January 2024
Source Peking University Third Hospital
Contact Yuan Wei, PhD, MD
Phone 01082267852
Email weiyuanbysy@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection Project. This project is funded by the Ministry of Science and Technology of China under grant number 2023YFC2705900. The ChiTwiMC cohort is led by Professor Wei Yuan from the Department of Gynecology and Obstetrics at Peking University Third Hospital.


Description:

The ChiTwiMC Cohort focusing on the serious complications of twin pregnancy, establish a multicenter large prospective mother-child cohort of twin pregnancy covering pregnancy→neonatal period→early childhood, and a multi-variety, multi-stage biobank for the study of adverse outcomes of twin pregnancy. The ChiTwiMC Cohort is planning to recruit 2000 pregnant women aged 18-45 years from 9 large obstetrical center of major University-affiliated Hospitals across China, between December 2023 and May 2026. All women will be enrolled prior to 14 wks of gestation, pregnancy was followed up at 22-28 wks, 30-38 wks of gestation, delivery, postpartum 42 days, 6 months, 12 months. Data including demographics, medical history, reproductive history, clinical diagnosis, treatment information, and pregnancy and birth outcomes will be collected via electronic data capture system. Track the outcome of severe maternal-fetal complications and early neonatal outcomes of twins, and collect biological samples, including peripheral venous blood, hair and cervicovaginal secretions from pregnant women, placenta tissue, amniotic fluid and unbilical cord blood at delivery, meconium and hair from newborns, buccal mucosa from infants and peripheral venous blood from the husband.


Recruitment information / eligibility

Status Recruiting
Enrollment 2000
Est. completion date November 30, 2026
Est. primary completion date November 30, 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - Twin pregnancies - Female aged between 18-45 years - Gestational age is less than 14 weeks - Planning to receive prenatal healthcare and delivery service at the study hospital - Signing informed concent and willing to participate Exclusion Criteria: - Women with mental disorders or serious maternal illness that is not eligible to participate - Inability to provide informed consent - Pregnant women not registered in our hospital

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
China Chongqing Medical University Chongqing Chongqing
China First Affiliated Hospital, Sun Yat-Sen University Guangzhou Guangdong
China The First Affiliated Hospital of Anhui Medical University Hefei Anhui
China Shandong Provincial Hospital Jinan Shandong
China The Second Hospital of Shandong University Jinan Shandong
China Peking University Peking Beijing
China Peking University Third Hospital Peking Beijing
China International Peace Maternity and Child Health Hospital Shanghai Shanghai
China Shanghai First Maternity and Infant Hospital Shanghai Shanghai
China Shengjing Hospital Shenyang Liaoning
China Nankai University Tianjin Tianjin

Sponsors (11)

Lead Sponsor Collaborator
Peking University Third Hospital Chongqing Medical University, First Affiliated Hospital, Sun Yat-Sen University, International Peace Maternity and Child Health Hospital, Nankai University, Peking University, Shandong Provincial Hospital, Shanghai First Maternity and Infant Hospital, Shengjing Hospital, The First Affiliated Hospital of Anhui Medical University, The Second Hospital of Shandong University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Rate of preterm delivery Preterm delivery is defined as delivery between 28 and 37 gestational weeks. From inclusion to delivery
Primary Rate of preeclampsia Preeclampsia is defined as the condition occurring in pregnant women after 20 weeks of gestation, characterized by systolic blood pressure =140 mmHg and/or diastolic blood pressure =90 mmHg, accompanied by any of the following: a urinary protein quantification =0.3 g/24 h, or a urine protein/creatinine ratio =0.3, or random urine protein = (+) (as a method of examination when protein quantification is not feasible). In the absence of proteinuria, the condition may still be diagnosed if there is involvement of any organ or system, including but not limited to critical organs such as the heart, lungs, liver, kidneys, or abnormalities in the hematological, digestive, or neurological systems, as well as complications affecting the placenta-fetus. From inclusion to delivery
Primary Rate of twin-to-twin transfusion syndrome (TTTS) TTTS is diagnosed in monochorionic diamniotic twin pregnancies when there is a discordance in amniotic fluid volumes, with one fetus exhibiting polyhydramnios and the other oligohydramnios. Specifically, before 20 weeks of gestation, the condition is diagnosed if one fetus (the recipient) has a deepest vertical pocket (DVP) of amniotic fluid =8cm, while the other fetus (the donor) has a DVP =2cm; after 20 weeks of gestation, the diagnosis is made if one fetus (the recipient) has a DVP =10cm, while the other fetus (the donor) has a DVP =2cm. From inclusion to delivery
Primary Rate of selective fetal growth restriction (sFGR) sFGR is diagnosed in monochorionic diamniotic twin pregnancies when one fetus has an estimated fetal weight below the 10th percentile for its gestational age, and there is a discrepancy of =25% in the estimated fetal weights between the two fetuses. From inclusion to delivery
Primary Rate of fetal brain injury Fetal brain injury is an abnormality in the structural and functional integrity of the cerebrum, cerebellum, or brainstem during the gestational period, caused by various factors such as hypoxic-ischemic events, infections, hemorrhage, congenital malformations, and genetic metabolic disorders. From inclusion to delivery
Primary Rate of neonatal brain injury Brain injury refers to damage to the central nervous system resulting from various risk factors during pregnancy, childbirth, and the neonatal period. Clinically, it manifests as central motor disorders, cognitive impairments, language disorders, visual and auditory impairments, as well as difficulties in social interaction and psychological and behavioral disorders. It needs pregnant history or birth history, (such as one of twin intrauterine fetal death, Intrauterine distress), manifestation, and ultrasound, CT, MRI, electroencephalogram to make a definite diagnosis. From inclusion to delivery
Primary Rate of early childhood developmental delay of the offspring Early childhood developmental delay of the offspring refers to a significant lag or delay in achieving age-appropriate developmental milestones across one or more domains, including cognitive, language, motor, social-emotional, and adaptive skills, during the early years of life (typically from birth to 5 years of age) in comparison to established norms or peers. The assessment of early childhood developmental delay is conducted using standardized scales such as Ages Stages Questionnaires (Third Edition), Gesell Developmental Schedules, and Bayley Scales of Infant and Toddler Development. The actual measurement process will be depending on the routine pediatric settings and resources available at each participating institution. Within 1 year after delivery
Primary Children's height Each child is measured twice. If the difference is less than 0.1 cm, the average of the two measurements is taken. If the difference is greater than 0.1 cm, the measurement is repeated. Within 1 year after delivery
Primary Children's weight Each newborn is measured twice. If the difference is less than 0.01 kg, the average of the two measurements is taken. If the difference is greater than 0.01 kg, the measurement is repeated. Within 1 year after delivery
Secondary Rate of sleep disorders Women's physiological and psychological changes during pregnancy will affect sleep, and the occurrence of bad sleep during pregnancy is more common. It is generally assessed by a sleep questionnaire. From inclusion to delivery
Secondary Rate of mental and phycological disorders Maternal mental health is as important as physical health, and good maternal mental health helps to promote the physical and mental health of the baby, as well as their own physical condition and natural childbirth. The condition of pregnant women is generally assessed by psychiatric departments. From inclusion to delivery
Secondary Rate of single intrauterine fetal demise The death of one fetus for twin pregnancy,the occurrence in the second and third trimesters of pregnancy has substantial adverse effects on surviving infants. From inclusion to delivery
Secondary Rate of gestational hypertension Take two consecutive measurements on the same arm, the systolic blood pressure more than 140 mmHg and (or) the diastolic blood pressure more than 90 mmHg. High blood pressure may lead to severe complications such as preclampsia and clampsia. From inclusion to delivery
Secondary Rate of gestational diabetes mellitus Diagnosed with gestational diabetes through an oral glucose tolerance test (OGTT). The blood glucose threshold of fasting, 1 h and 2 h after taking oral glucose was 5.1, 10.0, 8.5 mmolL, respectively, and the blood glucose level reached or exceeded the above criteria at any time point was diagnosed as GDM. GDM is clearly associated with adverse pregnancy outcomes such as fetal macrosomia, cesarean section delivery, preterm birth, and preeclampsia From inclusion to delivery
Secondary Number of maternal death Deaths during pregnancy or less than 42 days after termination of pregnancy. From inclusion to delivery
Secondary Rate of stillbirth After 28 gestational weeks, the fetus dies before or during delivery From inclusion to delivery
Secondary Birth weight Each newborn is measured twice. If the difference is less than 0.01 kg, the average of the two measurements is taken. If the difference is greater than 0.01 kg, the measurement is repeated. At delivery
Secondary Birth length Each newborn is measured twice. If the difference is less than 0.1 cm, the average of the two measurements is taken. If the difference is greater than 0.1 cm, the measurement is repeated. At delivery
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