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Interest of sFlt1/PlGF Ratio at Obstetric Emergencies — AngioCHIC  

Pre-Eclampsia Clinical Trial

Official title:
AngioCHIC : Interest of sFlt1/PlGF Ratio at Obstetric Emergencies

Clinical Trial Summary

In patients with suspected placental vascular disease who do not require hospitalization, the use of the sFlt-1 (Soluble FMS like tyrosin-kinase-1)/PlGF (Placental Growth Factor)/ assay can most likely help teams to define the best possible management.

Clinical Trial Description

Preeclampsia is a serious obstetric condition, affecting 2 to 5% of pregnancies and associated with maternal hypertension and renal dysfunction. It is a constant concern of obstetrical teams in the pre and post partum period. In case of diagnosis in the emergency unit, patients are usually hospitalized. However, in the case of a diagnosis of preeclampsia has been invalidated, but in presence of isolated or frustrated clinical functional signs, in the case of a history of placental vascular pathology, obstetric teams implement surveillance strategies that are binding on the patients. The sFlt-1/ PlGF assay has a high negative predictive value for the coming week. The use in clinical practice of these two biomarkers in the indication of negative prediction at one week could help teams in their management but the interest of this use needs to be evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04170660
Study type Observational
Source Centre Hospitalier Intercommunal Creteil
Contact
Status Active, not recruiting
Phase
Start date November 18, 2019
Completion date December 2023
View Details
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