Elderly Clinical Trial
Official title:
The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function
This is a longitudinal study supported by Pfizer and is a collaboration between DMPI (Duke Molecular Physiology Institute) and DIAL (Duke Image Acquisition Laboratory) to measure the effects of acute exercise on carnitine and acylcarnitine levels in the muscle and on insulin sensitivity in the plasma. This pilot study seeks to explain why moderate intensity exercise provides more improvements in glucose control for pre-diabetic patients than vigorous intensity. The investigators hypothesize that moderate intensity exercise might be beneficial for elderly individuals who are overweight or obese, specifically by: 1. Reducing damaging excess protein acetylation (measured in muscle biopsy), 2. Improving the acylcarnitine/carnitine ratio (measured by MRS), 3. Improving overall mitochondrial function as reflected in reduced phosphocreatine recovery time (measured by MRS) and 4. Increasing insulin sensitivity as measured by a 4-hour oral glucose tolerance test. Investigators intend to use the results of this study to show feasibility in measuring mitochondrial function at Duke for a larger federal grant submission. Investigators hypothesize that carnitine insufficiency might contribute to mitochondrial dysfunction and obesity-related impairments in glucose tolerance and insulin action.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05531396 -
Agility Training on Physical Performance, Cognitive Function and Brain Activities in Elderly
|
N/A | |
| Completed |
NCT03580447 -
The Effect of Citrus Extract on Oxidative Stress
|
N/A | |
| Recruiting |
NCT04096547 -
Rivaroxaban in Elderly NVAF Patients With or Without Renal Impairment
|
||
| Completed |
NCT03339791 -
Sleeve Versus Bypass in Older Patients: a Randomized Controlled Trial
|
N/A | |
| Completed |
NCT03566719 -
Effect of an Exercise Program on Risk of Fall in a Community Dwelling Older Adults
|
N/A | |
| Completed |
NCT02138968 -
Clinical and Economic Assessment of a Pre-frail Screening Program
|
N/A | |
| Completed |
NCT01368029 -
Safety of Lactobacillus Rhamnosus GG Vs. Placebo in Elderly Subjects Receiving Trivalent Inactivated Influenza Vaccine
|
Phase 1 | |
| Not yet recruiting |
NCT01182961 -
The Use of Virtual Reality for the Gait Training of Elderly Fallers
|
N/A | |
| Completed |
NCT00961012 -
The Big Squeeze (Lessening the Big Squeeze: The Effect of the Trunk Release on Interface Pressures of Individuals Seated in a High Fowler's Positions)
|
N/A | |
| Completed |
NCT01899586 -
Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly
|
N/A | |
| Completed |
NCT00748683 -
Development of an Integrated Health Care Environment for Elderly With RFID Technology
|
Phase 0 | |
| Completed |
NCT00533065 -
Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone
|
N/A | |
| Completed |
NCT00324701 -
Telepsychology-Service Delivery for Depressed Elderly Veterans
|
N/A | |
| Completed |
NCT00798668 -
The Body's Response to Food Intake in Trained, Older Adults
|
N/A | |
| Completed |
NCT00217113 -
An Intervention to Preserve Functional Status and Independence Among Community Dwelling Elderly
|
N/A | |
| Completed |
NCT03666793 -
Comprehensive Management of Drug Prescriptions Throughout the Elderly Person's Hospital Care
|
N/A | |
| Recruiting |
NCT06030804 -
Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery
|
N/A | |
| Recruiting |
NCT05014750 -
Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events
|
||
| Completed |
NCT05021432 -
Virtual Reality And Task Oriented Circuit Training Among Elderly Population
|
N/A | |
| Active, not recruiting |
NCT04132492 -
AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients
|