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Study TO Prevent Diabetes With Short-term Insulin Glargine Only — STOP-GO  

Pre-diabetes Clinical Trial

Official title:
A Multicenter, Randomized, Controlled Trial to Prevent Diabetes With Short-term Insulin Glargine Treatment or Lifestyle Intervention

Clinical Trial Summary

- Pre-diabetes is a significant risk factor for the development of type 2 diabetes, as well as macrovascular and microvascular complication.

- Previous studies show that 50% or more loss in islet B-cell function even in Pre-diabetes phase. The early insulin therapy in pre-diabetes may be a strategy in preventing metabolic disorders and cardiovascular disease.

- The objective of this study is to find if an initial insulin glargine intervention in pre-diabetes (IGT and /or IFG) could be a strategy in preventing type 2 Diabetes.

- Pre-diabetes subjects will receive a insulin glargine therapy with a dosage adjusted to get FBG ≤ 5.3mmol / L as the goal. Insulin glargine treatment will be maintained for three months thereafter to find if it can prevent diabetes.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01276912
Study type Interventional
Source Beijing Tongren Hospital
Contact Jin-Kui Yang, M.D., Ph.D.
Phone +86-10-58268445
Email jinkui.yang@gmail.com
Status Recruiting
Phase N/A
Start date January 2011
Completion date December 2013
View Details
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