Pouchitis Clinical Trial
Official title:
Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial
The aim of current study is to evaluate the effect of hyperbaric oxygen therapy for the treatment of chronic antibiotic-refractory pouchitis.
Pouch ischemia plays an important role in the pathogenesis of pouchitis after IPAA surgery
for ulcerative colitis. Obese Male patients are at high risk for pouchitis because of
mesenteric tension. Excessive weight gain is associated with an increased risk for pouch
failure in patients with restorative proctocolectomy. Also, patients with an 'S' pouch hardly
ever develop chronic pouchitis, owing to the additional length of bowel loop along with
mesentery when attached to the anal transitional zone. The treatment of chronic
antibiotic-refractory pouchitis(CARP) is difficult.
Hyperbaric oxygen therapy(HBOT) have been proven effecitve in the treatment of inflammatory
bowel diseases(IBD). Meta-analysis revealed that the overall response rate was 86% (85% CD,
88% UC), and of the endoscopic response rate to HBOT is 100%. The possible mechanism might be
due to the prmoted wound healing by increasing oxygen delivery to hypooxic tissues and
changes in inflammatory and immunological mediators.
Therefore, the aim of current study is to examine the therapeutic effect of HBOT for chronic
antibiotic-refractory pouchitis(CARP).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04979832 -
GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery
|
Phase 1/Phase 2 | |
| Terminated |
NCT00061282 -
Clotrimazole Enemas for Pouchitis in Children and Adults
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT05829109 -
Fecal Microbiota Transplant for Patients With Chronic Pouchitis
|
Early Phase 1 | |
| Recruiting |
NCT03136419 -
Microbiota and Immune microEnvironment in Pouchitis
|
N/A | |
| Withdrawn |
NCT04640155 -
Treating Chronic Pouchitis With a Low FODMAP Diet
|
N/A | |
| Completed |
NCT02201186 -
To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis
|
Phase 2 | |
| Completed |
NCT02790138 -
A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis
|
Phase 4 | |
| Not yet recruiting |
NCT01202396 -
The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis
|
N/A | |
| Completed |
NCT02428361 -
Fecal Microbiota Transplant (FMT) for Pouchitis
|
Early Phase 1 | |
| Completed |
NCT03538366 -
Fecal Microbiota Transplantation for Chronic Pouchitis
|
N/A | |
| Completed |
NCT04763564 -
Efficacy of Liraglutide Therapy in Patients With IPAA
|
Phase 2 | |
| Terminated |
NCT00583531 -
Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis
|
Phase 2 | |
| Recruiting |
NCT03524352 -
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis
|
Phase 3 | |
| Completed |
NCT04820413 -
Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
|
N/A | |
| Not yet recruiting |
NCT06443502 -
A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
|
Phase 3 | |
| Recruiting |
NCT04089345 -
Stelara fOr ChRonic AntibioTic rEfractory pouchitiS
|
Phase 3 | |
| Terminated |
NCT02782325 -
Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP)
|
Phase 1/Phase 2 | |
| Completed |
NCT02828410 -
Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA
|
N/A | |
| Recruiting |
NCT05578313 -
Inflammatory Bowel Diseases (IBD) Cannabis Registry
|
||
| Not yet recruiting |
NCT06316999 -
Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis
|
N/A |