Dopamine in Orthostatic Tolerance

Status Terminated

Clinical Trial Summary

One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome
Tachycardia

Clinical Trial Details

NCT number	NCT00748228
Study type	Interventional
Source	Vanderbilt University
Contact
Status	Terminated
Phase	N/A
Start date	November 2004
Completion date	July 2012

View Details

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