Clinical Trials Logo

Postural Tachycardia Syndrome clinical trials

View clinical trials related to Postural Tachycardia Syndrome.

Filter by:

NCT ID: NCT01791816 Active, not recruiting - Clinical trials for Postural Tachycardia Syndrome

Mechanisms of Vasovagal Syncope

Start date: February 2013
Phase: Early Phase 1
Study type: Interventional

Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness. Together they afflict many Americans, mostly young women, who are prevented from gainful employ or school attendance. The underlying mechanism is not known. Our past work suggests that a simple molecule, nitric oxide, acts to subvert normal blood flow controls causing blood to pool in the gut when standing. Our proposal will show the mechanism behind this problem and will indicate effective medical treatments. Patients will be compared to healthy control subjects.

NCT ID: NCT01783288 Active, not recruiting - Clinical trials for Postural Tachycardia Syndrome

Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening

Start date: February 2013
Phase: N/A
Study type: Interventional

The purpose of the study is to determine whether patients meet criteria for Postural Tachycardia Syndrome (or not) and have reduced blood volume (or not). Both of these are important screening elements to Aim 3 of a National Institutes of Health Grant. The purposes of Aim 3 are to determine 1. whether a high dietary sodium level appropriately expands plasma volume in Postural Orthostatic Tachycardia, 2. whether plasma renin activity and aldosterone are modified appropriately by changes in dietary sodium in Postural Tachycardia Syndrome and 3. whether patients with Postural Tachycardia Syndrome have improvements in their orthostatic tachycardia and symptoms as a result of a high dietary sodium level.

NCT ID: NCT01764711 Completed - Clinical trials for Postural Tachycardia Syndrome

Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)

Start date: January 2013
Phase: N/A
Study type: Interventional

This study is to determine different chemical levels in the blood during a low salt diet. This study will compare normal volunteers to those with Postural Tachycardia Syndrome (POTS)

NCT ID: NCT01761825 Enrolling by invitation - Clinical trials for Postural Tachycardia Syndrome

The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome

Start date: December 2012
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether Ivabradine is an effective treatment for postural tachycardia syndrome.

NCT ID: NCT01366963 Completed - Clinical trials for Postural Tachycardia Syndrome

Cognitive Dysfunction in Postural Tachycardia Syndrome

Start date: March 2011
Phase: N/A
Study type: Observational

A common complaint among people with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This is very poorly understood. To better understand this cognitive dysfunction, the investigators will test people with POTS and people without POTS using various neuropsychiatric instruments. The investigators hypothesis is that people with POTS will have greater abnormalities on neuropsychiatric testing than normal controls.

NCT ID: NCT01308099 Completed - Clinical trials for Postural Tachycardia Syndrome

Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome

Start date: February 2011
Phase: N/A
Study type: Observational

The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS. This study will test whether the blood vessels of people with POTS will react differently to certain tests than people without POTS. The hypothesis of the study is: Patients with POTS will have vascular endothelial dysfunction compared with control subjects.

NCT ID: NCT01210430 Completed - Clinical trials for Postural Tachycardia Syndrome

Local Vasoconstriction in Postural Tachycardia Syndrome

Start date: July 2010
Phase: Early Phase 1
Study type: Interventional

The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of POTS in individual patients. Specific causes for POTS may vary from patient to patient. Patients will be compared to healthy control subjects. There is a treatment arm with a medication (losartan) that reduces the binding of angiotensin and increases NO. If the investigators know the specific biochemical mechanism the investigators may be able to offer further specific treatments to specific patients.

NCT ID: NCT01000350 Active, not recruiting - Clinical trials for Postural Tachycardia Syndrome

Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Start date: October 2009
Phase: N/A
Study type: Interventional

The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).

NCT ID: NCT00962728 Active, not recruiting - Clinical trials for Postural Tachycardia Syndrome

Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

Start date: July 2009
Phase: N/A
Study type: Interventional

The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.

NCT ID: NCT00770484 Completed - Clinical trials for Postural Tachycardia Syndrome

Effect of Exercise in OI

Start date: November 2008
Phase: N/A
Study type: Interventional

The main limitation patients with orthostatic intolerance (OI, or postural tachycardia syndrome, POTS) have to exercise is related to their increase in heart rate when standing. Main pharmacological treatment today is aimed at reducing heart rate with the use of betablockers (propanolol), this theoretically could also improve their exercise capacity; if their heart rate do not increase as much with the medication, they could exercise more. In addition, it has been suggested that in healthy volunteers subjected to head down tilt for 2 weeks (situation that produces a "simulated" transient POTS-like state) a single bout of intense exercise can improve orthostatic tolerance the day after exercising. The mechanisms involved in such response are not that clear but could be an increase in plasma volume already diminished in POTS patients. It seems likely that the same could be true for POTS patients. The purpose of the present study are to pharmacologically improve the amount of exercise POTS patients can perform by reducing their baseline heart rate (specific aim 1) and to evaluate next day heart responses to an acute bout of intense exercise. Therefore, the specific aims of this study are: 1. To test the hypothesis that lowering heart rate response with propanolol will result in an increase in exercise capacity. 2. To test the hypothesis that a single bout of exercise will result in an improvement in orthostatic tolerance the day after exercising.