Posttraumatic Stress Disorders Clinical Trial
Official title:
Evaluating the Neurobiological Basis of Traumatic Dissociation in a Cross-Diagnostic Sample of Women With Histories of Childhood Abuse and Neglect
Verified date | October 2023 |
Source | Mclean Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study aims to evaluate the neurobiological basis of traumatic dissociation in a cross-diagnostic sample of women who have histories of childhood abuse and neglect.
Status | Enrolling by invitation |
Enrollment | 200 |
Est. completion date | June 2024 |
Est. primary completion date | June 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 89 Years |
Eligibility | Inclusion Criteria: - Female - Clinical diagnosis of PTSD or DID and history of childhood abuse, or healthy controls - Age between 18 and 89 - Legal and mental competency of the patient Exclusion Criteria: - Male - Under 18 or over 89 - Legal or mental incompetence - Delirium secondary to medical illness - PTSD or DID due to general medical or neurological illness - History of neurological conditions that may cause significant psychiatric symptomatology (e.g., dementia) - Any contraindication to MR scans, including claustrophobia, pregnancy, metal implants, etc. - Current alcohol or substance dependence or abuse (within the last month) - A history of schizophrenia or other psychotic disorder - History of head injury or loss of consciousness for longer than 5 min (including concussion) |
Country | Name | City | State |
---|---|---|---|
United States | McLean Hospital | Belmont | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Mclean Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from Baseline correlates of traumatic dissociation in Functional Magnetic Resonance Imaging at 36 to 56 weeks | Study participation will involve a baseline 60 minute cognitive assessment and a 60 minute Magnetic Resonance Imaging (MRI) at the 3 Tesla magnet in the McLean Hospital Imaging Center focusing on attention, emotion regulation, and symptoms of depersonalization. The first time point is baseline.The second time point will be 36-56 weeks after the baseline 60 minute Magnetic Resonance Imaging (MRI) scan at the 3 Tesla magnet in the McLean Hospital Imaging Center. | Baseline and 36 to 56 weeks after baseline |
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