Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function

Posttraumatic Stress Disorders Clinical Trial

Official title:

Cognitive Training for PTSD: Effects on Cognitive, Emotional, and Brain Function

Clinical Trial Details — Status: Unknown status

Administrative data

• NCT number: NCT01644851
• Other study ID #: UMKC SS11-212e
• Status: Unknown status
• Phase: N/A
• First received: July 17, 2012
• Last updated: December 4, 2014
• Start date: July 2012
• Est. completion date: July 2015

Study information

• Verified date: December 2014
• Source: University of Missouri, Kansas City
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.

Description:

Many posttraumatic stress disorder (PTSD) patients either choose not to complete or do not achieve optimal response to current first-line behavioral and pharmacologic treatments. Neurocognitive research points to the potential of novel treatments targeting dorsal prefrontal function and inhibition, attention, and working memory processes. This study investigates effects of computer-based training in executive functions compared to word games on cognitive and emotional aspects of combat-related PTSD. Paper-and-pencil questionnaires, interviews, computer-administered testing, and magnetic resonance imaging will be complete before and after the intervention. Results from this pilot study will provide information concerning feasibility and treatment potential of cognitive training for PTSD.

Recruitment information / eligibility

• Status: Unknown status
• Enrollment: 40
• Est. completion date: July 2015
• Est. primary completion date: July 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• combat veterans who served in Operation Iraqi Freedom, Operation Enduring Freedom, or Operation New Dawn

Exclusion Criteria:

• enrolled in other active treatment protocols

• current substance abuse or dependence

• current suicidal ideation

• diagnosis of a neurological disorder

• history of moderate to severe traumatic brain injury

Related Conditions & MeSH terms

• Posttraumatic Stress Disorders
• Stress Disorders, Post-Traumatic
• Stress Disorders, Traumatic

Intervention

Behavioral:
• Executive function training
Computer-based training in executive functions, administered via www.lumosity.com website.

Locations

Country	Name	City	State
United States	Univesity of Missouri - Kansas City	Kansas City	Missouri

Sponsors (2)

Lead Sponsor	Collaborator
University of Missouri, Kansas City	University of Kansas

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Clinical PTSD symptoms as measured by the Clinician Administered PTSD Scale (CAPS).		change from baseline to after 6 weeks of training
Primary	Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.		change from baseline to after 6 weeks of training
Secondary	Cognitive functioning as measured by neuropsychological assessment.		change from baseline to after 6 weeks of training