Posttraumatic Stress Disorder Clinical Trial
Official title:
Effectiveness of Screening and Treatment for PTSD in SUD Patients
This study proposes a prospective program of research that will identify feasible and inexpensive methods to detect and treat comorbid PTSD among VA SUD patients, thereby improving substance abuse treatment outcomes.
Background: This study proposes a prospective program of research that will identify feasible
and inexpensive methods to detect and treat comorbid PTSD among VA SUD patients, thereby
improving substance abuse treatment outcomes.
Objective(s): Our objectives are to test the effectiveness of substituting 2 hours/week of
Seeking Safety-based groups for standard substance use focused groups for male patients
attending outpatient substance use disorder treatment who meet clinical criteria for PTSD.
Primary outcomes measures will assess substance use disorder severity and secondary outcome
measures will assess mental health and substance use related problems plus treatment
satisfaction. We hypothesize that enhanced SUD treatment that incorporates "Seeking Safety"
will improve SUD treatment outcomes for PTSD-SUD patients as compared to outcomes for
PTSD-SUD patients receiving treatment as usual. Additionally, we examine two hypothesized
models via which "Seeking Safety" may effect substance use outcomes. We examine whether 1)
reductions in PTSD symptomatology and 2) improvements in coping strategies used in response
to PTSD symptoms (reductions in using to cope and other avoidance coping strategies)
partially mediate the effect of treatment on substance use outcomes.
Methods: This is a randomized clinical trial of 210 male veterans with PTSD and substance use
disorders attending outpatient substance use disorder treatment at the VA Oakland mental
health center. Patients will be randomized to 3 months of outpatient substance abuse
treatment including either 2 hours/week of "Seeking Safety" or standard addiction focused
group therapy. Data will be collected in patient interviews at treatment entry and at 3, 6
and 12 months after treatment initiation and by medical record review. Substance use, PTSD
symptomatology, mental health, social functioning, legal problems, use of coping techniques,
and treatment satisfaction outcomes will be assessed at treatment entry and 3, 6 and 12
months later using well-validated survey instruments. Primary and secondary treatment
outcomes of patients in "Seeking Safety" versus treatment as usual will be compared by
repeated measures ANCOVA. We will test the mediational hypotheses according to the 4-step
method described by Baron and Kenny (1986).
Status: Project began in January, 2006; Recruitment, treatment and assessment is complete and
primary trial finds are published. Secondary analysis is ongoing.
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