Postprandial Glucose Response Clinical Trial
Official title:
Effect of Degree of Polymerization and Linkage of α-glucans on Post-prandial Glucose Response
The primary research project objective is to investigate whether a maltodextrin with high degree of polymerization (Roquette Glucidex 2) and a dextran with comparable degree of polymerization (Pharmacosmos Dextran 10) have lower post-prandial glucose response than glucose syrup (Roquette Glucidex 40). To confer further robustness to the results, the post-prandial glucose response will be compared to a negative control represented by a resistant dextrin with a complex structure containing 70% non-digestible dietary fiber (Promitor 70), which is currently used for sugar replacement. Additional key objective is to investigate the safety and gastrointestinal tolerability of the investigational products.
The aim of the present research project is to generate comparative data on post-prandial glucose response (PPGR) of α-glucans varying systematically degree of polymerization and linkage type. These data are expected to contribute to the sugar replacement strategy in food industry. An additional goal of the study is to demonstrate the feasibility of running a PPGR study remotely, i.e. with the participants carrying out most of the procedures at home. Remote clinical trials (so called "virtual") have recently started to be implemented in pharmaceutical clinical research with the intent to reduce the burden on participants and investigational sites, narrow gaps with real life conditions, expand recruitment potential and maximize data collection. Nutritional research could be an even more suitable context for the remote approach because of the much lower safety risks for the participants. However, with this innovative approach come new risks (at distance communication with the participants, complex data flows and logistics, lower degree of control on clinical trial execution) that can potentially affect the reliability of the study results and therefore require proper mitigation. In the present study the following measures were put in place to reduce those risks: - Clear and complete instructions will be provided to the subjects on how the carry out remotely the study procedures. - Digital tools and devices used for data capture will be easy to use and the needed software will be pre-installed on a provided tablet. - An electronic questionnaire will be used to induce subjects to follow the study procedures and to assess compliance afterwards. - The heart rate and physical activity tracker will help determining if the subjects have followed the recommendation to avoid intense exercise in concomitance with the PPGR measurement - A certain time flexibility is allowed to accommodate the participants' needs and reduce the risk of drop-outs. - A conservative approach was used in the calculation of the sample size to reduce the risk of the study being underpowered in case of unexpected drop-out rate. - The Metabolic Unit staff will be reachable, during working hours, by the participants to provide technical support and to monitor their safety. - The study staff will be alerted via email every time that an adverse event is imputed in the adverse event collection tool. The two products selected as positive and negative control for the present research project. Comparison of PPGR data generated in the present research project with existing data will allow evaluating the reliability of the remote approach compared to the traditional one. ;
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