Postprandial Blood Glucose Clinical Trial
Official title:
Pharmacodynamic Profile of 'Blackadder' Blackcurrant Juice Effects Upon the Monoamine Axis in Humans
The current study uses a double-blind, placebo-controlled, randomised cross- over design to assess the pharmacodynamics of the platelet MAO-B inhibition, plasma prolactin levels and blood glucose levels after consumption of a single serve of 'Blackadder' blackcurrant juice.
There is emerging evidence which supports health benefits of consuming blackcurrant fruit,
including improvements to cognitive performance, modulation of blood flow, regulation of
blood glucose and inhibition of enzymes underpinning normal cognitive function. Of
particular relevance is our previous demonstration of inhibition of MAO-A and B after
consumption of a New Zealand 'Blackadder' blackcurrant juice drink in man.
In an attempt to establish a "therapeutic window" on which future nutritional interventions
can be based, the current study will assess the pharmacodynamics of MAO-B inhibition, plasma
prolactin levels and venous blood glucose profile following consumption of the 'Blackadder'
blackcurrant juice. The trial will utilise a 500mg dose of the 'Blackadder' juice
(equivalent to ~100g of fresh fruit) which was shown to have MAO inhibitory effects in our
previous report and effects will be measured in a cohort of healthy male adults.
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Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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