Postoperative Clinical Trial
Official title:
Exploratory Study Regarding the Use of Neurophysiological Monitoring Techniques to Detect Spinal Cord Ischemia in Patients After Thoracoabdominal Aortic Aneurysm Repair
During open surgery of a thoraco-abdominal aortic aneurysma (TAAA), diminished blood flow to the myelum can result in hypoxia, compromising proper function of the spinal cord. Intraoperatively, motor evoked potentials (MEP) are elicited to measure the functional integrity of the spinal cord. MEPs have proven to be a reliable marker of spinal cord ischemia. Moreover, these potentials react within minutes, which facilitates interventions to restore the blood flow. Monitoring intraoperatively with this ancillary test has reduced the rate of paraparesis to < 5%. Unfortunately, in the early postoperative period, spinal cord vulnerability is high. Therefore, some patients develop paraparesis, not during the surgical procedure, but after the surgical procedure. Postoperatively, suboptimal blood flow may lead to critical loss of function. This inadequate perfusion results in "delayed paraparesis". In the postoperative patient, it is not possible to measure MEPs when sedation is decreased, due to the high intensity of the electrical stimulus, which is unacceptably painful in the unanesthetized or partially anesthetized patient. Therefore ancillary tests are needed which can detect spinal cord ischemia postoperatively early, thus preceding the phase with clinically overt paraparesis. The test should be reliable and easy to perform for an extended period of time (up to several days). The purpose of this study is to explore the usefulness of various neurophysiological tests regarding accuracy and feasibility for the detection of spinal cord ischemia. In particular, to find a diagnostic test which is acceptable for the unanesthetized or partially anesthetized patient and therefore can also be performed postoperatively. These tests will be examined in fully sedated as well as partially sedated patients. The following candidate tests will be examined: 1. Long loop reflexes (LLR) consisting of F-waves. 2. Oxygenation measurements of the paraspinal muscles using Near-infrared spectroscopy (NIRS).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05875480 -
The Effectiveness of Telerehabilitation After Arthroscopic Meniscus Repair
|
N/A | |
| Completed |
NCT00150865 -
Evaluation of Efficacy of Lumbar Plexus Bloc After Hip Surgery
|
N/A | |
| Completed |
NCT00235261 -
Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations
|
Phase 4 | |
| Completed |
NCT01725464 -
The Effect of Nasal Cannula During the First 2 Hours Postoperative in Patient Undergoing Thoracotomy
|
Phase 4 | |
| Recruiting |
NCT04754022 -
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
|
N/A | |
| Not yet recruiting |
NCT04566094 -
Lung Herniation After Uniportal VATS
|
||
| Completed |
NCT03726541 -
Hemodynamic Effects of Physiotherapy in the Early Postoperative Period
|
N/A | |
| Active, not recruiting |
NCT04764227 -
Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shanghai 17)
|
Phase 2 | |
| Terminated |
NCT01140529 -
Dexmedetomidine for the Treatment of Delirium After Heart Surgery
|
Phase 3 | |
| Completed |
NCT00864695 -
Role of Anesthesiologist-Patient Relationship
|
N/A | |
| Completed |
NCT00478023 -
A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy
|
Phase 3 | |
| Recruiting |
NCT05692804 -
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
|
||
| Not yet recruiting |
NCT01139424 -
Closure of Anastomotic Leaks in the Stomach and Esophagus by Endoscopic Suturing
|
N/A | |
| Completed |
NCT04213716 -
Comparison of the Efficacy of Calcium Hydroxide With Silver Nanoparticle and Conventional Calcium Hydroxide Intra Canal Medications on Post-Operative Pain in Symptomatic Root Canal Treatment Failure Cases:
|
Phase 2 | |
| Completed |
NCT03552887 -
Adverse Events During Physiotherapy at Intensive Care Unit In Patients Undergoing Cardiac Surgery
|
||
| Completed |
NCT02543580 -
TEAS-induced Analgesia: Dual vs Single Acupoints
|
N/A | |
| Recruiting |
NCT00451373 -
Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study
|
N/A | |
| Completed |
NCT00273169 -
Use of the PSA 4000 Monitor in the Post-Operative Period in Patients Undergoing Major Surgery
|
N/A | |
| Not yet recruiting |
NCT06178458 -
Pain Score and Opioid Consumption of Index and Previous Cesarean Delivery
|
||
| Completed |
NCT01454609 -
Safety and Efficacy of Bilateral Superficial Cervical Plexus Block in Thyroidectomy
|
Phase 2 |