The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery

Postoperative Recovery Clinical Trial

Official title:

Study on the Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery-A Single Center, Prospective, Randomized, Double-blind, Controlled Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06241131
• Other study ID #: 2023-501
• Status: Not yet recruiting
• Phase: Early Phase 1
• Start date: March 1, 2024
• Est. completion date: September 30, 2025

Study information

• Verified date: January 2024
• Source: Sichuan Provincial People's Hospital
• Contact: Zhang
• Phone: 13882705707
• Email: giggle5707[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trials to study and compare the effects of "desflurane with remifentanil anesthesia (study group)" and "sevoflurane with remifentanil anesthesia (control group)" for elective fundus surgery anesthesia. The main question it aims to answer are the characteristics of desflurane anesthesia in patients undergoing fundus surgery and to provide universal guidance for clinical application.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 220
• Est. completion date: September 30, 2025
• Est. primary completion date: December 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. ASA I-II, patients aged 18-65 years old;

2. Fundus surgery to be performed under general anesthesia ;

3. The expected duration of surgery is about 30-120 min ;

4. BMI: 18-30 kg/m2 ;

5. Those who signed the informed consent form and volunteered to participate in this trial

Exclusion Criteria:

1. Patients with known or suspected genetic susceptibility to malignant hyperthermia;

2. Patients with history of asthma;

3. Patients with severe heart diseases (NYHA = III, severe arrhythmia, etc.) and cerebral or pulmonary diseases, liver or kidney dysfunction; or with unstable vital signs;

4. Patients with history of long-term narcotic analgesics application, including sedative and antidepressant drugs;

5. Patients with history of psychotropic drug abuse within 3 months;

6. Patients with long-term alcohol abuse;

7. People with mental disorder and unable to communicate normally;

Related Conditions & MeSH terms

• Desflurane Anesthesia
• Postoperative Recovery

Intervention

Drug:
• Desflurane Inhalant Product
The Desflurane was inhaled at a starting concentration of 1 MAC, and remifentanil 0.1 µg/kg/min was continuously pumped intravenously.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Sichuan Provincial People's Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Recovery time	The length of time from stopping anesthesia to patient recovery (opening eyes)	up to 1 hour