Clinical Trials Logo

Clinical Trial Summary

Bronchoscopy is a promising technology for lung and bronchus disease detection and therapy. However, this procedure is associated with a relatively high risk of hypoxemia, coughing, wheezing, and dyspnea. Despite the fact that propofol is the most commonly used agent in procedure sedation, the narrow therapeutic index remains challenging. Esketamine is the s-enantiomer of ketamine with potent analgesic and sedative properties. This study aims to test the hypothesis that adding subanesthetic esketamine to propofol is non-inferior to propofol alone for bronchoscopy on the recovery profile and discharge from the hospital.


Clinical Trial Description

Bronchoscopy is one of the most common procedures to detect lung and bronchus disease. The procedure is generally uncomfortable and associated with a relatively high risk of hypoxemia, coughing, wheezing, and dyspnea. Therefore, physicians are placing increasing importance on the use of procedure sedation due to the demand for comfortable medical care. Propofol is an effective agent for sedation in bronchoscopy with rapid onset and recovery. However, the safety endpoints of propofol are not cost-effective, including injection pain, hypotension, apnea, airway compromise, and without a reversal agent. Specifically, the depressive effects on the respiratory system are more noteworthy in bronchoscopy, which may lead to hypoxia. These drawbacks may hinder functional recovery and delay the discharge time. Hence, physicians are searching for an optimal sedation regimen for bronchoscopy. Esketamine, the s-enantiomer of ketamine, is an N-methyl-D-aspartic acid receptor antagonist with potent analgesic and sedative properties. Evidence suggested that esketamine could be used as a component of sedative regimen in many settings, such as endoscopy and endoscopic retrograde cholangiopancreatography. Nevertheless, there remains an evidence gap in the efficacy and safety of esketamine used in bronchoscopy. Therefore, we conducted this study to test the hypothesis that low-dose esketamine as an adjuvant to propofol was non-inferior to propofol alone on the recovery profile and discharge from the hospital after ambulatory bronchoscopy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05643066
Study type Interventional
Source Fujian Provincial Hospital
Contact
Status Completed
Phase Phase 4
Start date December 7, 2022
Completion date December 21, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT05255120 - Hysterectomy - A Regional Intervention Study N/A
Completed NCT04112394 - Does Erector Spinal Block Improve Quality of Recovery After Laparoscopic Cholecystectomy N/A
Not yet recruiting NCT02534623 - Postoperative Quality of Recovery After Transurethral Resection of the Bladder N/A
Completed NCT02141412 - Intravenous Dexmedetomidine For The Quaity Of Emergence From General Anesthesia Phase 4
Not yet recruiting NCT05450172 - Impact of Postoperative Transitional Pain on Recovery After Thoracic Surgery
Not yet recruiting NCT06469515 - Older People's Neurocognitive Recovery After Cardiac Surgery
Not yet recruiting NCT04733703 - Impact of Postanesthesia Care Unit Delirium on Postoperative Quality of Recovery
Completed NCT05361460 - Patients Experiences of Early Postoperative Cognition
Recruiting NCT05596695 - Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting N/A
Active, not recruiting NCT05603364 - Effect of Postoperative Oral Carbohydrate Administration in Total Knee Arthroplasty Elderly Patients Early Phase 1
Completed NCT02921529 - TEAS Enhanced Recovery After Laparoscopic Colon Surgery N/A
Recruiting NCT06347770 - Effect of Probiotics Before Cesarean Section on Postoperative Recovery in Pregnant Women N/A
Not yet recruiting NCT05867264 - Effect of Early Postoperative Oral Carbohydrate on Postoperative Recovery of the Unilateral Knee Arthroplasty Early Phase 1
Recruiting NCT05879536 - The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
Recruiting NCT05843383 - Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery N/A
Completed NCT05331027 - The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery Phase 4
Not yet recruiting NCT03249701 - Electrical Acupoint Stimulation for Postoperative Recovery N/A
Recruiting NCT06305221 - Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy N/A
Recruiting NCT06341049 - Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial N/A
Completed NCT04304274 - Programmed Intermittent Bolus Infusion of Thoracic Paravertebral Block for Hepatectomy N/A