Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve

Status Completed

Clinical Trial Summary

Hypothesis: Electrical stimulation of the abdominal vagus nerve has anti-inflammatory effects which lead to a faster postoperative recovery after abdominal surgery. Aims: In the present study, the investigators want evaluate the anti-inflammatory effect of peroperative electrical stimulation of the vagus nerve. In addition, the investigators want to determine whether vagus nerve stimulation leads to a faster postoperative recovery. To this end, the following aims are formulated: 1. to determine whether vagus nerve stimulation leads to an improvement in gastrointestinal transit using radiological testing 2. to evaluate whether electrical stimulation of the vagus nerve leads to clinical improvement (daily questionnaire) 3. to show that electrical stimulation of the intra-abdominal vagus nerve reduces the inflammatory response to abdominal surgery

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02524626
Study type	Interventional
Source	KU Leuven
Contact
Status	Completed
Phase	Phase 3
Start date	July 1, 2017
Completion date	December 31, 2019

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04205058` - Coffee After Pancreatic Surgery	N/A
Completed	`NCT02232893` - Effect of TU-100 in Patients Undergoing Laparoscopic Colectomy	Phase 2
Not yet recruiting	`NCT05001763` - Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy	Phase 2
Active, not recruiting	`NCT04547868` - Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery	N/A
Completed	`NCT02815956` - Tibial Nerve Stimulation and Postoperative Ileus	N/A
Completed	`NCT02947269` - Prucalopride in Postoperative Ileus	Phase 3
Recruiting	`NCT05512741` - Intestinal Microbiota and Postoperative Ileus After Colorectal Surgery
Recruiting	`NCT04675606` - Implementing a Low Fiber Diet vs. Regular Diet in Postoperative Colorectal Patients With Ileostomies	N/A
Completed	`NCT02161367` - Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery	Phase 4
Completed	`NCT01956643` - Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation	N/A
Completed	`NCT00464425` - Electroacupuncture for Postoperative Ileus After Laparoscopic Colorectal Surgery	Phase 3
Completed	`NCT00402961` - Trial of Acupuncture for Reduction of Post-Colectomy Ileus	Phase 2
Terminated	`NCT04100265` - ANTERO-5: Gastric Motility in Postoperative Ileus	N/A
Recruiting	`NCT04090073` - Electroacupuncture Combined With Fast-track Perioperative Program for Laparoscopic Colorectal Surgery	N/A
Recruiting	`NCT03222557` - Electroacupuncture for Postoperative Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer	N/A
Withdrawn	`NCT02261454` - RCT Gum Chewing on Bowel Function After Abdominal Surgery in Children	N/A
Completed	`NCT02004652` - Prucalopride for Postoperative Ileus in Patients Undergoing Gastrointestinal Surgery	Phase 2
Completed	`NCT02639728` - The Effect of Coffee Consumption in Enhancing Recovery of Bowel Function Following Colorectal Surgery.	N/A
Completed	`NCT00509327` - Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery	Phase 4
Completed	`NCT03097900` - Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?	Phase 2