Postoperative Ileus Clinical Trial
Official title:
Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies
Postoperative ileus can cause the accumulation of secretions and gas, resulting in nausea,
vomiting and abdominal distension and pain. Prolonged paralytic ileus is one of the
commonest reasons for delayed recovery and discharge from hospital following abdominal
surgery. Advances in surgical techniques and peri-operative management such as the use of
laparoscopic surgery, thoracic epidural analgesia, early postoperative feeding and
mobilization, amongst others, have been shown to help in the resolution of postoperative
ileus.
Chewing gum, as a proxy for sham feeding, may accelerate the motility of the GI tract by
stimulating the cephalic phase of digestion and eliciting the release of multiple
promotility GI hormones. A number of small controlled studies evaluating the effect of
chewing gum on postoperative intestinal recovery in patients undergoing colorectal surgery
have been conducted. Decreased time for bowel function recovery and decreased hospital
length of stay have not been consistently documented, possibly owing to the insufficient
power of existing studies and study design issues. In addition, all previous studies have
been limited by their use of sugarfree gum, containing known motility agents (eg, sorbitol).
In this study, gum chewing was studied for its effect on women with surgical staging for
malignant gynecologic disease such as endometrial cancer, cervix cancer and ovarian cancer.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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