Postoperative Hypoxemia Clinical Trial
Official title:
Early Nasal High Flow Oxygen Therapy for Prevention of Postoperative Hypoxemia After Abdominal Surgery: A Multicenter Randomized Controlled Trial
To evaluate whether early application of nasal high flow oxygen therapy after extubation can reduce the incidence of postoperative hypoxemia (defined as a PaO2/FiO2 ratio <300) after abdominal surgery in patients with intermediate to high risk of postoperative pulmonary complications.
Postoperative hypoxemia complicates between 30 to 50% of patients after abdominal surgery.
Loss of functioning alveolar units and development of atelectasis after abdominal surgery
have been recognized as the underlying mechanisms responsible for postoperative hypoxemia.
Supplemental Oxygen administration is therefore widely recommended after extubation in the
postoperative period, especially in patients with high risk of postoperative respiratory
complications. Although oxygen therapy is effective in preventing the vast majority of
severe postoperative hypoxemia after extubation in surgical patients, respiratory failure
may occur, thus requiring endotracheal intubation and mechanical ventilation or therapeutic
use of non-invasive positive pressure ventilation (NPPV). In patients with postoperative
hypoxemia (defined as patients with a PaO2/FiO2 ratio <300), application of NPPV was found
to decrease the incidence of endotracheal intubation after abdominal surgery. Nevertheless,
use of NPPV in the postoperative period is responsible for organizational constraints and
increases healthcare utilization.
Nasal high flow cannula (NHFC) has been described as an attractive and well-tolerated method
of non-invasive oxygen delivery. Previous studies have shown that NHFC generates a low level
of positive airway pressure, increases end-expiratory lung volume and reduces airway
resistance, thus contributing to a reduction in work of breathing. To date, however, no
clinical trials have compared NHFC to standard oxygen therapy in the prevention of
postoperative hypoxemia after abdominal surgery in patients with intermediate to high risk
of postoperative pulmonary complications.
The primary objective of the study is to compare: 1- Standard oxygen therapy; 2- Nasal high
flow oxygen therapy after extubation in patients with intermediate to high risk of
postoperative pulmonary complications after abdominal surgery.
Our hypothesis is that, compared with standard oxygen therapy, early application of nasal
high flow oxygen therapy can reduce the need for postoperative NPPV for postoperative
hypoxemia (defined as PaO2/FiO2 ratio <300).
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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