Treatment of Postoperative Hypoparathyroidism Using Cultured Allogenic Parathyroid Cells

Postoperative Hypoparathyroidism Clinical Trial

Official title: Treatment of Postoperative Hypoparathyroidism Using Cultured Allogenic Parathyroid Cells

Status Not yet recruiting

Clinical Trial Summary

The idea of the project is to develop a method of treatment of postoperative hypoparathyroidism using cultured allogenic parathyroid cells.

Clinical Trial Description

The cells will be isolated and cultured from the parathyroid gland of brain-dead organ donors. Cells will be tested for the immunophenotype, viability, sterility and the production of parathyroid hormone. Cells will be co-cultured with the patients T-cells and the expression of perforin and granzyme B proteins will be assayed as well as the apoptosis/viability of parathyroid cells. Prepared cells will be used to treat the patients with postoperative hypoparathyroidism. The safety, tolerability and clinical efficacy will be studied. ;

Related Conditions & MeSH terms

• Hypoparathyroidism
• Postoperative Hypoparathyroidism

• NCT number: NCT05186883
• Study type: Interventional
• Source: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
• Contact: Andrei Hancharou, Dr
• Phone: +375296248972
• Email: hancharou@ibp.org.by
• Status: Not yet recruiting
• Phase: Phase 1/Phase 2
• Start date: March 1, 2022
• Completion date: December 31, 2023