Two Different Tranexamic Acid Regimens in Coronary Artery Bypass Surgery

Status Recruiting

Clinical Trial Summary

The primary aim of this study is to observe the effects of two different methods of administering tranexamic acid (i.v. bolus and i.v. infusion) routinely used intraoperatively in cardiovascular surgery, on patients' postoperative bleeding amounts. According to the hypothesis established in this study, it is anticipated that administering tranexamic acid as an i.v. bolus dose followed by an 8-hour continuous infusion will result in a more stable blood level compared to the sole i.v. bolus application, thereby being more effective in influencing postoperative bleeding levels. The study has been designed as a prospective observational research. The outcomes of two different tranexamic acid protocols applied during cardiovascular surgical procedures will be compared. The first group will consist of patients who receive a 10 mg/kg i.v. bolus of tranexamic acid after anesthesia induction, followed by an 8-hour i.v. tranexamic acid infusion at a dose of 2 mg/kg/hour. Group 2 will consist of patients who receive three doses of tranexamic acid, 10 mg/kg i.v. bolus after anesthesia induction, in the pump, and after protamine sulfate administration. The cases collected over a period of 6 months will be divided into two groups and compared in terms of intraoperative and postoperative bleeding levels, as well as their need for blood products.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05994989
Study type	Observational
Source	Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Contact	Osman Uzundere, MD
Phone	+905330206362
Email	osmanuzundere@gmail.com
Status	Recruiting
Phase
Start date	August 14, 2023
Completion date	May 21, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02963623` - Fibtem Predicts Postoperative Bleeding	N/A
Completed	`NCT00307138` - Hetastarch and Bleeding Complications After Off-Pump Coronary Bypass Surgery	Phase 3
Active, not recruiting	`NCT06114758` - Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy
Completed	`NCT03793816` - Tonsillectomy Using BiZact™ - a Randomized Side-controlled Clinical Trial	N/A
Terminated	`NCT05308589` - CPPF After General Cardiac Surgery	N/A
Completed	`NCT04505475` - Oral Surgery in Patients Taking Direct Oral Anticoagulants
Completed	`NCT05229276` - Efficacy of Sternum Guard in Post Cardiac Surgery Patient	N/A
Completed	`NCT05817474` - Efficacy of Local Infiltration of Tranexamic Acid and Lidocaine in Tonsillar Bed on Postoperative Bleeding and Pain During Tonsillectomy Surgery: Prospective, Randomized, Control Study	N/A
Terminated	`NCT02343263` - Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage	Phase 2
Not yet recruiting	`NCT06285656` - Femoral Blood Gas and Prediction of Postoperative Bleeding
Recruiting	`NCT04725305` - BiZact Tonsillectomy in the Pediatric Population	N/A
Recruiting	`NCT05889494` - Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients	N/A
Not yet recruiting	`NCT06450834` - Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE
Recruiting	`NCT01889732` - A Gray Zone Approach of Rotational Thromboelastometry for Predicting Postoperative Bleeding in Cardiac Surgical Patients	N/A
Completed	`NCT00337766` - Desmopressin in Cardiac Surgery	Phase 4
Completed	`NCT00587444` - Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass	Phase 3
Completed	`NCT06238739` - Optimal Temperature Control in Body Contouring Procedures	N/A
Recruiting	`NCT02709460` - Lateral Occlusion of Uterine Artery in Total Laparoscopic Hysterectomy	N/A
Completed	`NCT02627560` - The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy	Phase 4
Terminated	`NCT02358850` - Post-tonsillectomy Pain Control in Adults	Phase 4