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The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium

Postoperative Delirium Clinical Trial

Official title:
The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium: A Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study is to determine the efficacy and safety of Tropisetron in preventing emergence delirium.

Clinical Trial Description

Delirium is a common complication during postoperative period, especially in elderly patients. The presence of postoperative delirium is independently associated with poor recovery, increased length of hospital stay, the development of long-term cognitive decline and increased mortality.

Tropisetron is a 5-HT3A receptor antagonist and is widely used to treat postoperative nausea and vomiting. Previous studies found that tropisetron has positive effect on cognitive function. This study aims to access the efficacy and safety of tropisetron in preventing emergence delirium.

To explore the results differences amongst different patients, subgroup analysis will be conducted according to: a. Age (older than 65 years versus 65 years or younger); b. Surgery type (major surgery versus minor surgery); c. Preoperative MoCA scores (>26 versus 18-26 versus 10-17). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04027751
Study type Interventional
Source Beijing Chao Yang Hospital
Contact
Status Recruiting
Phase Phase 4
Start date August 1, 2019
Completion date March 31, 2022
View Details
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