Postoperative Delirium Clinical Trial
Official title:
Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium
Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1
week after surgery or before discharge. Old age is one of the important risk factors for
postoperative delirium. The incidence rate of the elderly is high, and the life span of human
beings is increasing. Postoperative delirium has adverse effects on both short-term and
long-term outcomes, including mortality, ability to work, and dependence on society.
Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is
easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density
lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have
shown that increased oxidative stress is one of the earliest changes in disease, and similar
signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment
(MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation
index. For the study of anesthesiology, oxidative stress theory has long been recognized as
one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized
low-density lipoprotein levels are associated with postoperative delirium and can be used as
an early warning marker for disease occurrence.
Based on clinical research data, we conducted a prospective cohort study to explore the
correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum,
providing clinical prediction and diagnostic value.
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