Clinical Trials Logo
  1. Home
  2. Postoperative Delirium
  3. NCT03683537
  4. Details
NCT03683537 Clinical Trial

Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Postoperative Delirium Clinical Trial

Official title:
Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03683537
Other study ID # MKNC 02/2018
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date February 15, 2018
Est. completion date September 15, 2019

Study information
Verified date June 2019
Source Moscow Clinical Scientific Center
Contact Sergey Kamnev, M.D.
Phone +0079055918462
Email korium1605@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date September 15, 2019
Est. primary completion date July 15, 2019
Accepts healthy volunteers No
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria:

- Patients with different diseases, who require prolonged laparoscopy or open surgery

- Age more than 60

- ASA I-III

- Informed consent to participate in the study

Exclusion Criteria:

- ASA IV-V

- Severe neurodegenerative or psychological diseases

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Glial fibrillary acidic protein
3 samples of serum are drawn from patients. The 1st Sample of patient serum is drawn before induction into anesthesia. The 2nd is drawn 24 hours after the 1st one. The 3rd sample is drawn on 3 or 4 postoperative day. All samples collected and preserved in the same temperature as required for ELISA.

Locations
Country Name City State
Russian Federation Moscow Clinical Scientific Center Moscow

Sponsors (1)
Lead Sponsor Collaborator
Moscow Clinical Scientific Center

Country where clinical trial is conducted

Russian Federation, 

Outcome
Type Measure Description Time frame Safety issue
Primary Changes in serum GFAP GFAP(3) - GFAP (1); GFAP (2) - GFAP (1) 1 year
See also
  Status Clinical Trial Phase
Completed NCT03606941 - Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery N/A
Recruiting NCT05990790 - The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium Phase 4
Completed NCT03950440 - Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement
Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Completed NCT02585128 - Predictors of Postoperative Delirium After Transcatheter Aortic Valve Implantation N/A
Recruiting NCT02227225 - Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly N/A
Recruiting NCT01934049 - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Phase 4
Terminated NCT00455143 - Cognitive Protection - Dexmedetomidine and Cognitive Reserve Phase 4
Recruiting NCT05010148 - A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain Phase 3
Completed NCT06178835 - EPO for Postop Delirium in Elderly Patients Phase 4
Recruiting NCT05992506 - Electroencephalographic Biomarker to Predict Postoperative Delirium
Recruiting NCT03839784 - Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Completed NCT04154176 - Validation of the Greek Version of the Confusion Assessment Method Diagnostic Algorithm (CAM) and the Nursing Delirium Screening Scale (Nu-DESC) and Their Inter-rater Reliablity
Not yet recruiting NCT06375265 - Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients N/A
Recruiting NCT05572307 - Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Active, not recruiting NCT03629262 - Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery Phase 4
Not yet recruiting NCT05537155 - Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery N/A
Completed NCT01964274 - Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients
Completed NCT01599689 - Pilot and Feasibility Study of a Mirrors Intervention for Reducing Delirium in Older Cardiac Surgical Patients N/A
Active, not recruiting NCT03291626 - Postoperative Delirium: EEG Markers of Sleep and Wakefulness