Postoperative Delirium at Heidelberg's Intensive Care Unit -New Diagnostic Markers

Postoperative Delirium Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00463333
• Other study ID #: 196/2004
• Status: Completed
• Phase: N/A
• First received: September 10, 2005
• Last updated: April 19, 2007
• Start date: May 2005

Study information

• Verified date: April 2007
• Source: Heidelberg University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Federal Institute for Drugs and Medical Devices
• Study type: Observational

Clinical Trial Summary

Summary:

Postoperative delirium is a highly prevalent disease (10–30% prevalence) after surgery in intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the present project is to investigate risk factors for postoperative delirium in more detail, to evaluate respective cognitive test systems and to measure EEG activity parallel to patients’ serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium. Because delirium is also associated with higher postoperative mortality and morbidity, with delayed functional recovery, and postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All patients at Intensive Care Unit over a defined time period

• Over 18 years old

Exclusion Criteria:

• Elective heart and vascular patients

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal

Related Conditions & MeSH terms

• Delirium
• Postoperative Delirium

Locations

Country	Name	City	State
Germany	Intensive Care Unit, Clinic of Anesthesiology	Heidelberg

Sponsors (2)

Lead Sponsor	Collaborator
Heidelberg University	Else Kröner Fresenius Foundation

Country where clinical trial is conducted

Germany,