Postoperative Delirium Clinical Trial
Summary:
Postoperative delirium is a highly prevalent disease (10–30% prevalence) after surgery in
intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the
present project is to investigate risk factors for postoperative delirium in more detail, to
evaluate respective cognitive test systems and to measure EEG activity parallel to patients’
serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a
possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely
hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be
a new prognostic factor for evaluation of delirium. Because delirium is also associated with
higher postoperative mortality and morbidity, with delayed functional recovery, and
postoperative delirium makes patient management much more difficult, increases costs, and,
above all, causes severe discomfort to the patient new interdisciplinary diagnostic
strategies are necessary to resolve this problem.
n/a
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
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