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Cardiac Surgery and Postoperative Organ Dysfunction

Postoperative Complications Clinical Trial

Official title:
Cardiopulmonary Bypass Ischemia/Reperfusion Injury and Postoperative Multiple Organ Dysfunction in Elder Patients

Clinical Trial Summary

The aim of the study is to identify the correlation between ischaemia reperfusion injury and postoperative multiorgan damage during cardiopulmonary cardiac surgery; and to investigate biomarkers that can predict postoperative organ damage in cardiac surgery.

Clinical Trial Description

This study proposes to observe multi-organ functional impairment of the heart, kidney and brain after extracorporeal circulation in a prospective study of clinical patients; to obtain markers with diagnostic and predictive efficacy by collecting pre and postoperative serum and heart and ear tissue samples from patients with postoperative organ functional impairment, performing combined proteomic and metabolomic analyses, and by analysing them with detailed postoperative clinical prognostic data using machine learning algorithms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05529212
Study type Observational
Source The Second Affiliated Hospital of Chongqing Medical University
Contact Qiao Guo, MD
Phone 13637870013
Email guoqiao@cqmu.edu.cn
Status Not yet recruiting
Phase
Start date September 16, 2022
Completion date November 30, 2023
View Details
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