Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04741555 |
| Other study ID # |
2020/295 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
June 1, 2020 |
| Est. completion date |
June 1, 2021 |
Study information
| Verified date |
June 2021 |
| Source |
Karadeniz Technical University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Open heart surgeries are one of the major and complicated surgeries performed frequently in
the world due to the prolongation of life expectancy and developments in medicine. As a
result of these operations, not only the heart and vessels, but also all organs and systems
depending on the systemic circulation are affected. Some biological inflammation markers have
been determinant in determining cardiovascular risk. High neutrophil count was associated
with increased mortality, while low lymphocyte count was a strong constant predictor of
mortality. In addition, increased serum uric acid (UA) levels have been found to be
associated with obesity, dyslipidemia, and hypertension, which is associated with
cardiovascular disease risk. The aim of this study is to investigate the effects of patients
who underwent coronary bypass surgery under elective conditions in Karadeniz Technical
University Faculty of Medicine between 2008-2020 on in-hospital and 1-year mortality based on
preoperative neutrophil / lymphocyte ratios and uric acid values.
Description:
Open heart surgeries are one of the major and complicated surgeries performed frequently in
the world due to the prolongation of life expectancy and developments in medicine. Mortality
rates are decreasing day by day, although more and more additional diseases are present and
older patients are taken in open heart surgery. The aim of these surgeries is to reduce the
risk of death by correcting existing cardiac pathologies and increasing the quality of life
of patients. For this reason, some studies have developed cardiac risk scoring methods in
preoperative evaluation in order to predict mortality before surgery, and created a risky
group such as advanced age, female gender, decreased left ventricular functions, those who
use postoperative intraaortic balloon pumps, and those who receive inotrope support.
Some biological inflammation markers have been determinant in determining cardiovascular
risk. High neutrophil count was associated with increased mortality, while low lymphocyte
count was a strong constant predictor of mortality. Cardiovascular bypass itself is related
to neutrophil activation, highlighting the effects of its high preoperative levels. Increased
neutrophil counts are related to blood viscosity and hypercoagulability. Also, decreased
lymphocyte count indicates increased physiological stress.
The importance of serum uric acid levels has been stated in many epidemiological studies as a
risk factor for cardiovascular diseases. Increased serum uric acid (UA) levels are associated
with obesity, dyslipidemia, and hypertension, which is associated with a risk of
cardiovascular disease. In another study, it was shown that the risk of cardiovascular
mortality and increased serum UA levels were independently and significantly related.
The aim of this study was to examine the short-term (first 30 days) and long-term (1 year)
mortality of patients who underwent elective coronary bypass surgery between 2008 and 2020 at
the Karadeniz Technical University Faculty of Medicine, based on preoperative neutrophil /
lymphocyte ratios and uric acid values. effects will be investigated
