Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation

Postoperative Complications Clinical Trial

Official title:

Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation- A Retrospective Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04188717
• Other study ID #: ILBS - Liver Transplant-2
• Status: Completed
• Start date: January 1, 2010
• Est. completion date: January 1, 2017

Study information

• Verified date: November 2019
• Source: Institute of Liver and Biliary Sciences, India
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation. The investigators aim to evaluate the incidence, risk factors and predictors of neurological complications in both living donor and deceased donor transplantation done in the hospital. Between January 2011 to December 2016, 253 liver transplant recipients were recruited for this study. The investigators recorded the incidence of neurological complications, their median time of onset, their relationship with etiology of chronic liver disease, and the risk factors for the complications. The investigators also studied the relationship of neurological complications with duration of hospital and ICU stay, and survival. Using multivariate forward regression analysis , the investigators developed a scoring system for prediction of neurological complications in liver transplantation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 253
• Est. completion date: January 1, 2017
• Est. primary completion date: December 31, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• patients undergoing liver transplant surgery

• 18-65 years

Exclusion Criteria:

• pregnant patients

• Acute Liver Failure, Acute on Chronic Liver Failure

Related Conditions & MeSH terms

• Liver Transplant; Complications
• Neurologic Complication
• Postoperative Complications

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Institute of Liver and Biliary Sciences, India

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neurological complications	type of neurological complication	90 days
Primary	Mortality	mortality due to any cause	90 days