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NCT02766062 Clinical Trial

Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

Postoperative Complications Clinical Trial

Official title:
Effects of Propofol and Sevoflurane on Early Postoperative Cognitive Dysfunction in Elderly Patients With Metabolic Syndrome

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02766062
Other study ID # NZ1651
Secondary ID
Status Completed
Phase N/A
First received May 1, 2016
Last updated June 29, 2016
Start date September 2015
Est. completion date May 2016

Study information
Verified date January 2016
Source General Hospital of Ningxia Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Description:

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Recruitment information / eligibility
Status Completed
Enrollment 94
Est. completion date May 2016
Est. primary completion date April 2016
Accepts healthy volunteers No
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria:

- aged =60 years;

- ASA?or ?

- noncardiac surgery and nonneural surgery

Exclusion Criteria:

- Mini Mental State Examination [MMSE] score too low

- chronic alcoho and drug abuse

- disturbed renal and liver function

- history of a cerebrovascular accident

- permanent ventricular pacing

- preoperative cognitive deficits

- lack of cooperation

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• metabolic syndrome
metabolic syndrome

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
General Hospital of Ningxia Medical University

Outcome
Type Measure Description Time frame Safety issue
Primary Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group up to 7days postoperatively
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