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Clinical Trial Summary

The aim of this study is to evaluate the effectiveness of intraoperative individualized positive end-expiratory pressure (PEEPIND) titration, compared to fixed positive end-expiratory pressure of 5 cmH2O, on oxygenation, hemodynamic variables, and early postoperative complications in obese patients undergoing laparoscopic bariatric surgery.


Clinical Trial Description

Obesity is a major health problem, and the incidence is increasing worldwide. So far, the only treatment for morbid obesity with good long-term results is bariatric surgery. Obese patients have unique respiratory physiology and ventilatory mechanics characteristics. Their lung function is impaired due to the reduction of oxygen reserve, functional residual capacity, and lung compliance. In addition, they frequently present with respiratory comorbidities, which increases the risk of developing postoperative pulmonary complications (PPCs) such as atelectasis especially after procedures under general anesthesia. Atelectasis has been hypothesized as a main cause of postoperative hypoxemia. To reduce the incidence of atelectasis, positive end-expiratory pressure (PEEP) and recruitment maneuvers are used as a protective lung strategy to improve gas exchange and lung mechanics through reopening collapsed alveoli and maintaining the aeration of lungs. Application of PEEP may also eliminate auto-PEEP without increasing plateau pressure. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06115668
Study type Interventional
Source Tanta University
Contact Heba Z Khattab, Master
Phone 00201004774825
Email hebazakaria194@gmail.com
Status Recruiting
Phase N/A
Start date November 5, 2023
Completion date April 1, 2024

See also
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Completed NCT05514366 - Influence of Inspiratory Pause on Ventilatory Efficiency in Robotic Surgery. A Prospective Paired Study. N/A
Completed NCT04030078 - A Central and Eastern European Survey On PEEP Titration and Alveolar Recruitment Manoeuvres During Surgery