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Postmenopausal Women and Their Endothelium

Postmenopausal Women Clinical Trial

Official title:
Postmenopausal Women and Their Endothelium: Is Dietary Nitrate Supplementation Protective

Clinical Trial Summary

The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

Clinical Trial Description

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. Function of the endothelium has been shown to decline across the menopause transition, resulting in less production of nitric oxide. As such the investigators are investigating a potential therapeutic strategy in women have recently undergone menopause to boost nitric oxide availability. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03644472
Study type Interventional
Source Penn State University
Contact
Status Completed
Phase Phase 2
Start date November 7, 2018
Completion date February 20, 2023
View Details
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