Postmenopausal Osteoporosis Clinical Trial
Official title:
Tainan Hospital, Ministry of Health and Welfare, Taiwan
Verified date | April 2024 |
Source | Tainan Hospital, Ministry of Health and Welfare |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Osteoporosis weakens bones with age, increasing fracture risk. Exercise improves physical function and reduces falls, crucial for preventing osteoporotic fractures, especially with balance, resistance, and multi-component training. Agility exercise, integrating various aspects like aerobic, strength, balance, and cognitive tasks, is promising for fall prevention in older adults, though its effectiveness in osteoporosis is not extensively studied. This study compares agility and resistance exercise impacts on physical function and balance stability in postmenopausal osteoporosis. Fifty-one women (average age: 68±6.3y, BMI: 22.3±2.7 kg/m2) were divided into agility exercise (AG), resistance exercise (RG), and control groups (CG) through purposive sampling. AG and RG received added intervention training once a week for 2 hours over 12 weeks. Main outcomes included physical function and balance stability measured through various tests.
Status | Completed |
Enrollment | 51 |
Est. completion date | December 31, 2022 |
Est. primary completion date | May 31, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: postmenopausal osteoporosis diagnosed with DXA( Hologic, W type, Caucasian reference, T-score?-2.5 in L-spine or hip) Exclusion Criteria: Unable to attend the training sessions due to physical problems Had joined previous exercise program |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chen, Ying-Chen | Tainan |
Lead Sponsor | Collaborator |
---|---|
Tainan Hospital, Ministry of Health and Welfare |
Taiwan,
Donath L, van Dieen J, Faude O. Exercise-Based Fall Prevention in the Elderly: What About Agility? Sports Med. 2016 Feb;46(2):143-9. doi: 10.1007/s40279-015-0389-5. — View Citation
Lichtenstein E, Morat M, Roth R, Donath L, Faude O. Agility-based exercise training compared to traditional strength and balance training in older adults: a pilot randomized trial. PeerJ. 2020 Apr 14;8:e8781. doi: 10.7717/peerj.8781. eCollection 2020. — View Citation
Miko I, Szerb I, Szerb A, Bender T, Poor G. Effect of a balance-training programme on postural balance, aerobic capacity and frequency of falls in women with osteoporosis: A randomized controlled trial. J Rehabil Med. 2018 Jun 15;50(6):542-547. doi: 10.2340/16501977-2349. — View Citation
Morat M, Morat T, Zijlstra W, Donath L. Effects of multimodal agility-like exercise training compared to inactive controls and alternative training on physical performance in older adults: a systematic review and meta-analysis. Eur Rev Aging Phys Act. 2021 Feb 25;18(1):4. doi: 10.1186/s11556-021-00256-y. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Physical function of upper limb strength | arm curl in 30 secs | after the completed training course, about 12 weeks | |
Primary | Physical function of upper limbs strength | Hand grip | after the completed training course, about 12 weeks | |
Primary | Physical function of lower limbs | Walking speed | after the completed training course, about 12 weeks | |
Primary | Physical function of dynamic balance | Up and go test | after the completed training course, about 12 weeks | |
Primary | Physical function of lower limbs | Sit to stand in 30 secs | after the completed training course, about 12 weeks | |
Primary | Physical function of static balance | One leg stand test | after the completed training course, about 12 weeks | |
Primary | Stability index | Biodex balance system device | after the completed training course, about 12 weeks |
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